DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and Frzb

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_035486.1	Gene:	Frzb / 20378	MGIID:	892032	Length:	323	Species:	Mus musculus

Alignment Length:	321	Identity:	92/321 - (28%)
Similarity:	131/321 - (40%)	Gaps:	68/321 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGL 96
            |.|.|.:|..||....|  ..:..:|......||.:.||:|:.:.:|||..||.::|.||..|.|
Mouse     5 GPGRMLLGWAGLLVLAA--LCLLQVPGAQAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAIL 67

  Fly    97 EVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDY-HKPLPVCRSVCERARSGCAPIMQQYSFEWPE 160
            .:.||..|:...|||||.||||:||.|||..|: |:|:..|:|||||||.||.||:.:|...|||
Mouse    68 AMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPE 132

  Fly   161 RMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSG 225
            .:||:.||::  ...:|:...:...|........|                   |.|...|.||.
Mouse   133 SLACDELPVY--DRGVCISPEAIVTADGADFPMDS-------------------STGHCRGASSE 176

  Fly   226 STSTKPCRGRNSKNCQNPQGE--KASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMN 288
            ....||.|.......:|....  :|..||....|......:..:::|:..
Mouse   177 RCKCKPVRATQKTYFRNNYNYVIRAKVKEVKMKCHDVTAVVEVKEILKAS--------------- 226

  Fly   289 LTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFII----DTER 345
                 :..:|               :|...|:..  || |.|..|.....::|    |.||
Mouse   227 -----LVNIP---------------RDTVNLYTT--SG-CLCPPLTVNEEYVIMGYEDEER 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	56/119 (47%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	11/42 (26%)
Frzb	NP_035486.1	CRD_SFRP3	32..157	CDD:143550	56/126 (44%)
		NTR_Sfrp3_like	188..297	CDD:239636	18/115 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840