Protein Alignment fz2 and cfz-2

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_503965.2
• Gene: cfz-2 / 178768
• WormBaseID: WBGene00000478
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 645
• Identity: 239/645 - (37%)
• Similarity: 332/645 - (51%)
• Gaps: 122/645 - (18%)

  Fly    63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLE 127
            :||:||||:|:|||||||||||...||.|:|||||||||:||||:.|...||||||:||||||.|
 Worm    24 KCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQE 88

  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGD---PDNLCMEQPSYTEAGSG 189
            :|.||:..|..:|..|||.|:|||.:|.|.|||.::||.||...|   ..|:|...|
 Worm    89 NYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPP-------- 145

  Fly   190 GSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQN----------PQ 244
                                                .|..|..:|.:.|| ||          |.
 Worm   146 ------------------------------------DTPKKQHKGHHHKN-QNQNQNQNHNYSPD 173

  Fly   245 GEK-----------ASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVP 298
            |.:           |...||.|:|..|..|:..|:                       .::..|.
 Worm   174 GPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEK-----------------------SKVGNVT 215

  Fly   299 NCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMV 363
            ||...|..|..: :.......|:|.||..|......|..||:|:|:||:||||||..|:.|..||
 Worm   216 NCAYSCHSPALA-ESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMV 279

  Fly   364 AVGYLSRNFLQNEEIACDGLLLRESSTGPHS-CTLVFLLTYFFGMASSIWWVILSFTWFLAAGLK 427
            |||::.|.|:.:||||||.:.::.:.....| |.:|||||||||||:|:||||||.||.|:|..|
 Worm   280 AVGFMIRYFVGHEEIACDSMRIKGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASK 344

  Fly   428 WGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYL 492
            |..|||:..|.:||:..|.:|.:|:|.|::.:|:|||||.|||||||.:....:.|||.||.||.
 Worm   345 WSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGDPITGICYVGNTDLQFQRIFVLFPLLVYF 409

  Fly   493 VIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEA 557
            ::|..||:.||.:|:.||:.:::|.  .:...|.|:.:||.:|||||:|||:|:.::|....||.
 Worm   410 IVGVLFLVIGFCNLWSIRNEVQKQH--PSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQ 472

  Fly   558 AYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLG 622
            .:...|.::..|.|:..:..|...|. :.::|......:|.|||.|:.|.|||.||:       .
 Worm   473 NHRSLWEQSQLCSCSPKQTIGDSSLI-ISLIKTCCMCILGWTSGFWVCSTKTLSSWK-------N 529

  Fly   623 APDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHHLH 682
            |....|::::|.|.:|                  |..|.|.....:......|..|:||:
 Worm   530 AICCLGSSRSLPKYQP------------------ADILYAKSDMSSSQFYNTSLRHNHLY 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	72/121 (60%)
		Frizzled	308..618	CDD:279827	132/310 (43%)
cfz-2	NP_503965.2	CRD_FZ5_like	24..146	CDD:143565	73/165 (44%)
		Frizzled	230..532	CDD:279827	133/311 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165984
Domainoid	1	1.000	269	1.000	Domainoid score	I973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	424	1.000	Inparanoid score	I983
Isobase	1	0.950	-	0	Normalized mean entropy	S2842
OMA	1	1.010	-	-		QHG49270
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	1	1.000	-	-		FOG0003114
OrthoInspector	1	1.000	-	-		oto17199
orthoMCL	1	0.900	-	-		OOG6_106776
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4396
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890