DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and sfrp-1

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_500977.2	Gene:	sfrp-1 / 177401	WormBaseID:	WBGene00022242	Length:	314	Species:	Caenorhabditis elegans

Alignment Length:	272	Identity:	67/272 - (24%)
Similarity:	102/272 - (37%)	Gaps:	98/272 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PVIPKDPNLRCEEI--TIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFW-PLVEIKCSPDLKF 115
            ||.||     |.:|  .:.:|.||.|.....||.:.|||..|| :...:.| .|:.:.|.||.:.
Worm    32 PVGPK-----CVDIPSNLSICNGIEYTQMRLPNILEHETVSEA-IHASKDWESLLRLNCHPDTQR 90

  Fly   116 FLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCME- 179
            ||||::.|:||....:.:..|:|:|...:.||...|..|.|.|||.::||..    :.|::|::
Worm    91 FLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKF----EDDDMCIKP 151

  Fly   180 -QPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPC----------- 232
             ||:...|||                                     ||:...|
Worm   152 MQPAKPPAGS-------------------------------------STTCTACSQVATYENLVD 179

  Fly   233 ---------------------RGRNSKNCQNPQGEKASG-----------KECSCSCRSPLIFLG 265
                                 |.||.::.:  :||:..|           .:.||.|..| :...
Worm   180 QFCRSHLVLKAKVIRDSPTHIRVRNGRSLK--KGERRRGVSDVEIRLSSESDGSCPCNIP-VKNQ 241

  Fly   266 KEQLLQQQSQMP 277
            .|:||...|:.|
Worm   242 NEKLLVMASRQP 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	41/123 (33%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
sfrp-1	NP_500977.2	CRD_FZ	37..161	CDD:382974	43/128 (34%)
sfrp-1	NP_500977.2	NTR_Sfrp1_like	162..283	CDD:239635	18/95 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810