Protein Alignment fz2 and sfrp-1

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_500977.2
• Gene: sfrp-1 / 177401
• WormBaseID: WBGene00022242
• Length: 314
• Species: Caenorhabditis elegans
• Alignment Length: 272
• Identity: 67/272 - (24%)
• Similarity: 102/272 - (37%)
• Gaps: 98/272 - (36%)

  Fly    54 PVIPKDPNLRCEEI--TIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFW-PLVEIKCSPDLKF 115
            ||.||     |.:|  .:.:|.||.|.....||.:.|||..|| :...:.| .|:.:.|.||.:.
 Worm    32 PVGPK-----CVDIPSNLSICNGIEYTQMRLPNILEHETVSEA-IHASKDWESLLRLNCHPDTQR 90

  Fly   116 FLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCME- 179
            ||||::.|:||....:.:..|:|:|...:.||...|..|.|.|||.::||..    :.|::|::
 Worm    91 FLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKF----EDDDMCIKP 151

  Fly   180 -QPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPC----------- 232
             ||:...|||                                     ||:...|
 Worm   152 MQPAKPPAGS-------------------------------------STTCTACSQVATYENLVD 179

  Fly   233 ---------------------RGRNSKNCQNPQGEKASG-----------KECSCSCRSPLIFLG 265
                                 |.||.::.:  :||:..|           .:.||.|..| :...
 Worm   180 QFCRSHLVLKAKVIRDSPTHIRVRNGRSLK--KGERRRGVSDVEIRLSSESDGSCPCNIP-VKNQ 241

  Fly   266 KEQLLQQQSQMP 277
            .|:||...|:.|
 Worm   242 NEKLLVMASRQP 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	41/123 (33%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163
		TM helix 1	316..341	CDD:320163
		TM helix 2	350..371	CDD:320163
		TM helix 3	396..422	CDD:320163
		TM helix 4	439..455	CDD:320163
		TM helix 5	477..506	CDD:320163
		TM helix 6	531..558	CDD:320163
		TM helix 7	579..604	CDD:320163
sfrp-1	NP_500977.2	CRD_FZ	37..161	CDD:470581	43/128 (34%)
		NTR_Sfrp1_like	162..283	CDD:239635	18/95 (19%)