Protein Alignment fz2 and mom-5

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001300437.1
• Gene: mom-5 / 172856
• WormBaseID: WBGene00003397
• Length: 570
• Species: Caenorhabditis elegans
• Alignment Length: 672
• Identity: 208/672 - (30%)
• Similarity: 300/672 - (44%)
• Gaps: 159/672 - (23%)

  Fly    13 LVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGY 77
            |:|.|..|.      |||..:....:       |...|:..       ..:||.||||||:.:.|
 Worm     6 LILFLFGCL------SADQRLSSTSI-------SSMNGFST-------TRKCEHITIPMCKNLDY 50

  Fly    78 NMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVCRSVC 140
            |.|.|||.:.|.||.|||..:.||.||:::|||.|::.|||::|.|:|  ||   ||:..||.:|
 Worm    51 NQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLE---KPIQPCRELC 112

  Fly   141 ERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSG 205
            ..|::||..:|:::.|:||:::.|...|:
 Worm   113 LSAKNGCESLMKKFGFQWPDQLDCNKFPV------------------------------------ 141

  Fly   206 GKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLL 270
                                   |..|.|:||....|.:..::|..          :..|...:.
 Worm   142 -----------------------TDLCVGKNSSESSNSKNYRSSND----------VTFGVSTIA 173

  Fly   271 QQQSQMPMM--HHPH-----HWYMNLTVQRIAGVPNCGIPCKGP-----FFSNDEKDFAGLWIAL 323
            .:....|..  ||.|     |:.:.|...|:   |.|.:.|:..     .|....:....:|.|.
 Worm   174 NEVVLSPKKCPHHMHTTSGSHFSLPLLSGRL---PECSLTCEADNQVPMMFDGRVRRILRIWTAA 235

  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRES 388
            ||..||..:|.||.||::|..||.||.|||::|:.||..::..|:. ..:..:..|| |......
 Worm   236 WSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMI-GVVGEDGFAC-GTYGSTP 298

  Fly   389 ST-----GPH-SCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLI 447
            :|     |.: .|:.:.::.|||.|:|..||::|...|||||.||||.|:|...|.|||...|.:
 Worm   299 TTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGV 363

  Fly   448 PTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSV 512
            |.|.||.||:.::||||...|||.||||||..|..|...|:.|.|.:|...|:.|..|:.||||.
 Worm   364 PAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSY 428

  Fly   513 IK-QQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEA----AYFEDWIKALA---- 568
            || |...|...:  .||||||:|||.|:::|::|..:......|:|    |:.|.|:....
 Worm   429 IKLQHADVERNI--SKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGWLHHRCVRLQ 491

  Fly   569 -------------CPC-AQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRR 619
                         ||. .:|..|.    ..|.:|||...|.||||..:|:.|.|||.|:.:
 Worm   492 DRELFGFTYPVDDCPMDPKVAAPE----IIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHK---- 548

  Fly   620 LLGAPDRTGANQALIKQRPPIP 641
                     |..||..:.|.:|
 Worm   549 ---------AYLALSSRSPTVP 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	50/120 (42%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	126/344 (37%)
		TM helix 1	316..341	CDD:320163	11/24 (46%)
		TM helix 2	350..371	CDD:320163	7/20 (35%)
		TM helix 3	396..422	CDD:320163	9/25 (36%)
		TM helix 4	439..455	CDD:320163	8/15 (53%)
		TM helix 5	477..506	CDD:320163	9/28 (32%)
		TM helix 6	531..558	CDD:320163	10/30 (33%)
		TM helix 7	579..604	CDD:320163	9/24 (38%)
mom-5	NP_001300437.1	CRD_FZ1_like	35..147	CDD:143567	52/173 (30%)
		7tmF_Frizzled_SMO	219..550	CDD:320089	126/351 (36%)
		TM helix 1	228..253	CDD:320089	11/24 (46%)
		TM helix 2	262..282	CDD:320089	7/20 (35%)
		TM helix 3	312..338	CDD:320089	9/25 (36%)
		TM helix 4	355..371	CDD:320089	8/15 (53%)
		TM helix 5	393..422	CDD:320089	9/28 (32%)
		TM helix 6	446..473	CDD:320089	9/26 (35%)
		TM helix 7	512..537	CDD:320089	10/28 (36%)