Protein Alignment fz2 and lin-17

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001021813.1
• Gene: lin-17 / 171832
• WormBaseID: WBGene00003006
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 164/568 - (28%)
• Similarity: 254/568 - (44%)
• Gaps: 103/568 - (18%)

  Fly    63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLE 127
            :|..|.|.:|:.:.||.|.|||.:.|..|.........|.||::.||.|.:.||:||::.|:|..
 Worm    27 KCIPIDIELCKDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPI 91

  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSS 192
            ...:.:..|:||||:.::.|..|::::...|||.:.|...|   ||..||| :|:..|...|.|:
 Worm    92 GMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFP---DPPELCM-KPTEDEITGGFSA 152

  Fly   193 GGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSC 257
            ......|                        |.|:|:||                       ..|
 Worm   153 PRLPTKG------------------------SSSSSSKP-----------------------TGC 170

  Fly   258 RSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCK-GPFFSNDEKDFAGLWI 321
            .|.|:.:..             |.|.              .:|...|: ...||.|.|.....|
 Worm   171 PSDLVDVDP-------------HDPK--------------SHCAFACQSNVMFSTDNKRMVRSW- 207

  Fly   322 ALW-----SGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD 381
            ::|     :|:    .|.:..||.||.:||::|||.:.:||.|.|:.::.||:..|:.....:|.
 Worm   208 SIWFAAANAGV----ALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPLFIDAPIRSCH 268

  Fly   382 GLLLRES--STGPHS---CTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFH 441
            .|....|  |.|...   |...|||.|||..|:::||::.|||.:|:.|.||..|.|...|.|.|
 Worm   269 ALGNGRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVH 333

  Fly   442 LAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSL 506
            ..||.:.::.::.||:.:.||...:..:|.|||||...|..||:.|..:.:||||.|::.||.|:
 Worm   334 FVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASM 398

  Fly   507 FRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPC 571
            .|.|...:.:     |....||||||:::|.|..|:.:|..|.:.|..|:......|.: :...|
 Worm   399 CRERISFRTR-----GTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKFMILTQWTR-MTIDC 457

  Fly   572 AQVKGPGKKPL---YSVLMLKYFMALAVGITSGVWIWSGKTLESWRRF 616
            .|..|...:|.   ..:.|.....:||.|.:..:|:.|.||:.:|:.|
 Worm   458 KQQSGACHRPTPPQAEIYMTAVISSLATGFSCLMWVLSAKTVHAWKNF 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	41/118 (35%)
		Frizzled	308..618	CDD:279827	106/322 (33%)
lin-17	NP_001021813.1	CRD_LIN_17	25..144	CDD:143563	42/120 (35%)
		Frizzled	195..506	CDD:279827	106/322 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2842
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860