DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and Fzd9

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_034376.1 Gene:Fzd9 / 14371 MGIID:1313278 Length:592 Species:Mus musculus


Alignment Length:615 Identity:252/615 - (40%)
Similarity:341/615 - (55%) Gaps:110/615 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 MGMGGHGLD---------ASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQ 91
            :..||..|:         ..|||              |:.:.||||||||||:|..||.:.|.:|
Mouse    17 LATGGAALEIGRFDPERGRGPAP--------------CQAMEIPMCRGIGYNLTRMPNLLGHTSQ 67

  Fly    92 DEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSF 156
            .||..::.:|.|||:..|...|:|||||:|.|:|.:....|:|.||.:||:||..|||||:|::|
Mouse    68 GEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNF 132

  Fly   157 EWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAG 221
            .||:.:.|..||...||..||||.|   |..:.|.:....|.|....:....:..|..:.|.|:|
Mouse   133 GWPDSLDCARLPTRNDPHALCMEAP---ENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGPGSG 194

  Fly   222 GSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWY 286
            |:                |.||  ||....|.|.||                             
Mouse   195 GT----------------CDNP--EKFQYVEKSRSC----------------------------- 212

  Fly   287 MNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPER 351
                      .|.|| |....|:|..:||||.:|:|:||.|||.||..|:.||:::..||:||||
Mouse   213 ----------APRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPER 266

  Fly   352 PIVFLSACYFMVAVGYLSRNFLQNEEIACD---GLL--LRE--SSTGPHSCTLVFLLTYFFGMAS 409
            ||:|||.||.:.::.:|.|.....:.:|||   |.|  ::|  .:||   |||||||.|:|||||
Mouse   267 PIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMAS 328

  Fly   410 SIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGN 474
            |:|||:|:.|||||||.|||:|||..|..|||:|||.:|.::::.||.|..|.||.:.|:|||.:
Mouse   329 SLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVVLTLRKVAGDELTGLCYVAS 393

  Fly   475 LNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFS 539
            ::|..|..|||.||..|||:||:||:.|||:||.||.::|.     .|...:||||||::||:||
Mouse   394 MDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFS 453

  Fly   540 VLYTVPATIVIGCYLYEAAYFEDW-IKALACPCAQVKGPGKK----------PLYSVLMLKYFMA 593
            :|||||||.||.||:||....:.| ::|...||.....||.:          |..:|.|||.||:
Mouse   454 ILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAATVPGGRRDCSLPGGSVPTVAVFMLKIFMS 518

  Fly   594 LAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
            |.||||||||:||.||.::|:....|.:.|
Mouse   519 LVVGITSGVWVWSSKTFQTWQSLCYRKMAA 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 58/118 (49%)
Frizzled 308..618 CDD:279827 163/327 (50%)
Fzd9NP_034376.1 CRD_FZ9 36..162 CDD:143572 63/142 (44%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 59..173 50/116 (43%)
7tmF_FZD9 222..543 CDD:320164 163/328 (50%)
TM helix 1 231..256 CDD:320164 14/24 (58%)
TM helix 2 265..286 CDD:320164 10/20 (50%)
TM helix 3 315..341 CDD:320164 19/25 (76%)
TM helix 4 358..374 CDD:320164 7/15 (47%)
TM helix 5 396..426 CDD:320164 17/29 (59%)
TM helix 6 445..472 CDD:320164 19/26 (73%)
TM helix 7 504..529 CDD:320164 15/24 (63%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 533..538 2/4 (50%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 555..592
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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