DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz2 and Fzd8

DIOPT Version :9

Sequence 1:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_032084.2 Gene:Fzd8 / 14370 MGIID:108460 Length:685 Species:Mus musculus


Alignment Length:738 Identity:355/738 - (48%)
Similarity:424/738 - (57%) Gaps:151/738 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICL 126
            |.|:|||:|:|:|||||.|..||:.||:||||||||||||||||||:||||||||||||||||||
Mouse    33 LACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICL 97

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |||.||||.||||||||::||||:|:||.|.||:||.|:.||..|:||.|||:. :.|:..:...
Mouse    98 EDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDY-NRTDLTTAAP 161

  Fly   192 S-------GGSGGSGSGSGSGGKRKQGG--SGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEK 247
            |       ....|....||||..|..|.  ...||| :.||..:.:..|.||..::    |.|..
Mouse   162 SPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGS-SRGSGDAAAAPPSRGGKAR----PPGGG 221

  Fly   248 ASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSND 312
            |:..|..|.||:|::.:..|:              |..|..:...:||   ||.:||..||||.|
Mouse   222 AAPCEPGCQCRAPMVSVSSER--------------HPLYNRVKTGQIA---NCALPCHNPFFSQD 269

  Fly   313 EKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEE 377
            |:.|...||.|||.|||.||..|::||:||.||||||||||:||||||..|:||||.|....:|:
Mouse   270 ERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEK 334

  Fly   378 IACDG------------------------------------------LLLRESSTGPHSCTLVFL 400
            :||.|                                          ..:|..:|||..||:|||
Mouse   335 VACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFL 399

  Fly   401 LTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDP 465
            |.|||||||||||||||.|||||||:|||||||..:||||||||||:|:|:|:|||.||:|||||
Mouse   400 LVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDP 464

  Fly   466 ILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEK 530
            :.|||||||.:.|:|:.||||||.:||.|||.||:||||||||||||||||||   ..|..||||
Mouse   465 VAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGG---PTKTHKLEK 526

  Fly   531 LMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGP--GKKPLYSVLMLKYFMA 593
            ||||:|:|:|||||||.:|:.|..||......|.....|||.:...|  .::|.|:|.||||||.
Mouse   527 LMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMC 591

  Fly   594 LAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAG 658
            |.||||||||:||||||||||....|...|                        ..|..||:.||
Mouse   592 LVVGITSGVWVWSGKTLESWRALCTRCCWA------------------------SKGAAVGAGAG 632

  Fly   659 SLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHVXHGESGGASTMGGGGGGGSTLGGGTL--- 720
                                                  |...|.|..|.|||||...|||:|   
Mouse   633 --------------------------------------GSGPGGSGPGPGGGGGHGGGGGSLYSD 659

  Fly   721 -------GHGTAMSSSTVGMGPL 736
                   ..|||.|.|.....||
Mouse   660 VSTGLTWRSGTASSVSYPKQMPL 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 88/118 (75%)
Frizzled 308..618 CDD:279827 204/353 (58%)
Fzd8NP_032084.2 CRD_FZ8 31..155 CDD:143570 89/122 (73%)
Palmitate-binding groove 71..78 6/6 (100%)
Wnt-binding 95..100 4/4 (100%)
Wnt-binding 147..152 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..223 18/72 (25%)
7tmF_FZD8 264..616 CDD:320378 205/354 (58%)
TM helix 1 273..298 CDD:320378 14/24 (58%)
TM helix 2 307..328 CDD:320378 15/20 (75%)
TM helix 3 395..417 CDD:320378 19/21 (90%)
TM helix 4 438..454 CDD:320378 11/15 (73%)
TM helix 5 476..499 CDD:320378 14/22 (64%)
TM helix 6 529..554 CDD:320378 15/24 (63%)
TM helix 7 577..602 CDD:320378 17/24 (71%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 606..611 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..656 14/62 (23%)
PDZ-binding 683..685 355/738 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 416 1.000 Domainoid score I660
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 637 1.000 Inparanoid score I827
Isobase 1 0.950 - 0 Normalized mean entropy S2842
OMA 1 1.010 - - QHG49270
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 1 1.000 - - FOG0003114
OrthoInspector 1 1.000 - - otm43526
orthoMCL 1 0.900 - - OOG6_106776
Panther 1 1.100 - - O PTHR11309
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4396
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.820

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