DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and Fzd7

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_032083.3	Gene:	Fzd7 / 14369	MGIID:	108570	Length:	572	Species:	Mus musculus

Alignment Length:	642	Identity:	282/642 - (43%)
Similarity:	369/642 - (57%)	Gaps:	121/642 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKVLILGLV-LLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITI 69
            |..|:|.|: .|.|..||. |.    ||..|:.:..||.                    |:.|:|
Mouse    15 LCALVLALLGALPTDTRAQ-PY----HGEKGISVPDHGF--------------------CQPISI 54

  Fly    70 PMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLP 134
            |:|..|.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|.. ..:.:|
Mouse    55 PLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIP 118

  Fly   135 VCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSG 199
            .|||:|||||.||..:|.::.|:||||:.||:.|:|| ...:|:                  |..
Mouse   119 PCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHG-AGEICV------------------GQN 164

  Fly   200 SGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNP-QGEKASGKECSCSCRSPLIF 263
            :..|||             |||||..:..|.|..........:| .|........||
Mouse   165 TSDGSG-------------GAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSC-------- 208

  Fly   264 LGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-------FFSNDEKDFAGLWI 321
                   .:|.::|    |:..|      |..|..:||.||: |       :|..:|:.||.||:
Mouse   209 -------PRQLKVP----PYLGY------RFLGERDCGAPCE-PGRANGLMYFKEEERRFARLWV 255

  Fly   322 ALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC------ 380
            .:||.||..|||.|:.|:::|..||.||||||:|||.|||||||.::: .||..:...|
Mouse   256 GVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVA-GFLLEDRAVCVERFSD 319

  Fly   381 DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAW 445
            ||.......|....||::|::.|||||||||||||||.|||||||:|||:|||..:|||||||||
Mouse   320 DGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAW 384

  Fly   446 LIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIR 510
            .:|.|:::.:|.:..||||.:.|:||||..:.|.|:.||||||||||.|||:||:||||||||||
Mouse   385 AVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIR 449

  Fly   511 SVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKAL 567
            :::|..     |.|.:||||||:|||:||||||||||||:.||.||.|:.|.|        .|:.
Mouse   450 TIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSY 509

  Fly   568 ACPCAQVKGPG----KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            |.||.    ||    ..|.::|.|:||.|.:.||||:|.||||||||:|||||:.||
Mouse   510 AVPCP----PGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	60/118 (51%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	180/327 (55%)
Fzd7	NP_032083.3	CRD_FZ7	45..169	CDD:143575	63/163 (39%)
		7tmF_FZD7	241..571	CDD:320374	182/332 (55%)
		TM helix 1	250..275	CDD:320374	13/24 (54%)
		TM helix 2	284..305	CDD:320374	14/21 (67%)
		TM helix 3	335..361	CDD:320374	19/25 (76%)
		TM helix 4	378..394	CDD:320374	9/15 (60%)
		TM helix 5	416..445	CDD:320374	21/28 (75%)
		TM helix 6	465..492	CDD:320374	21/26 (81%)
		TM helix 7	521..546	CDD:320374	11/24 (46%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	550..555		3/4 (75%)
		PDZ-binding	570..572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810