DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and Fzd6

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001155966.1	Gene:	Fzd6 / 14368	MGIID:	108474	Length:	709	Species:	Mus musculus

Alignment Length:	719	Identity:	217/719 - (30%)
Similarity:	321/719 - (44%)	Gaps:	146/719 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFL 117
            :|::.......||.||:|.|..:.||||.|||.|.|..|..|.:|:..|..|..::|||:::.||
Mouse    13 LPLVRGHSLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLHLANLECSPNIEMFL 77

  Fly   118 CSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPS 182
            |..:.|.|.|..|..|| ||.:||:..|.|..:|..:...|||.:.|..|| |.| |.:.:....
Mouse    78 CQAFIPTCTEQIHVVLP-CRKLCEKIVSDCKKLMDTFGIRWPEELECNRLP-HCD-DTVPVTSHP 139

  Fly   183 YTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEK 247
            :||..                                              |...|:.|.|
Mouse   140 HTELS----------------------------------------------GPQKKSDQVP---- 154

  Fly   248 ASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSND 312
               ::....|...|...|.:.                       .|..|:..|..||...:|.:|
Mouse   155 ---RDIGFWCPKHLRTSGDQG-----------------------YRFLGIEQCAPPCPNMYFKSD 193

  Fly   313 EKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEE 377
            |.|||..:|.:.|..|.|:||.|..||:||..||:||||||::.|.||.:|::.|.. .||....
Mouse   194 ELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFV-GFLLGNS 257

  Fly   378 IAC----------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEA 432
            .||          |.::|...:   .:|::||:..|||.||.::|||||:.|||||||.||..||
Mouse   258 TACNKADEKLELGDTVVLGSKN---KACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEA 319

  Fly   433 ITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTT 497
            |.:.:.:||..||..|...:|.:|.::.|:||.|.|:|:||..:.|..:.|||.||.:.:.:|.:
Mouse   320 IEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLS 384

  Fly   498 FLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLY------- 555
            .|:||.:||..:|.||:..|.     ..:||:|.|||||:||.||.||...::|||:|
Mouse   385 LLLAGIISLNHVRQVIQHDGR-----NQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRIT 444

  Fly   556 -EAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRR 619
             |..:|.|.......||.....|..:|..::.|:||.|.|.|||::..|:.|.||...|..|::|
Mouse   445 WEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509

  Fly   620 LLGAPDRTGANQAL-------IKQRPPIPH--------PYAGSGMGMPVGSAAGSLLATPYTQAG 669
            .......:.:.:.|       :|....:.|        |:....:...:|::.|:.     |..|
Mouse   510 NRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHGAPGPHRLKVISKSMGTSTGAT-----TNHG 569

  Fly   670 GASVASTSHHHLHHHVLKQ-------------------PAASHVXHGESGG-ASTMGGGGGGGST 714
            .:::|...|.:|......:                   |:|.....|||.| :|.:.|...|..:
Mouse   570 TSAMAIADHDYLGQETSTEVHTSPEASVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGRES 634

  Fly   715 LGGG 718
            ..||
Mouse   635 RAGG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	48/118 (41%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	131/327 (40%)
Fzd6	NP_001155966.1	CRD_FZ6	20..146	CDD:143559	50/174 (29%)
		7tmF_FZD6	188..508	CDD:320160	131/328 (40%)
		TM helix 1	198..222	CDD:320160	10/23 (43%)
		TM helix 2	231..252	CDD:320160	9/21 (43%)
		TM helix 3	283..305	CDD:320160	12/21 (57%)
		TM helix 4	326..342	CDD:320160	6/15 (40%)
		TM helix 5	364..387	CDD:320160	7/22 (32%)
		TM helix 6	418..440	CDD:320160	11/21 (52%)
		TM helix 7	469..494	CDD:320160	9/24 (38%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..709		11/56 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810