Protein Alignment fz2 and Fzd3

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_067433.1
• Gene: Fzd3 / 14365
• MGIID: 108476
• Length: 666
• Species: Mus musculus
• Alignment Length: 690
• Identity: 222/690 - (32%)
• Similarity: 315/690 - (45%)
• Gaps: 164/690 - (23%)

  Fly    38 MGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFW 102
            :|||.|                  ..||.||:.||:.:.||.|..||.:||..|..|.|.:..|.
Mouse    20 IGGHSL------------------FSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFH 66

  Fly   103 PLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHL 167
            |:|.:.||.|.:.|||::|.|||:|.....|| ||.:|:||.|.|:.:|:.:...|||.|.|...
Mouse    67 PMVNLDCSRDFRPFLCALYAPICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMECSRF 130

  Fly   168 P-------------LHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSG 219
            |             |.|||          ||               |:....:|..|
Mouse   131 PDCDEPYPRLVDLNLVGDP----------TE---------------GAPVAVQRDYG-------- 162

  Fly   220 AGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHH 284
                                                      .:..:|..:........:|
Mouse   163 ------------------------------------------FWCPRELKIDPDLGYSFLH---- 181

  Fly   285 WYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYP 349
                        |.:|..||...:|..:|..||..:|.|.|.:|..:||.|..||:||..||:||
Mouse   182 ------------VRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYP 234

  Fly   350 ERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGL--LLRESST---GPH--SCTLVFLLTYFFGM 407
            ||||:|.:.||.||::.:.. .||..:.:||:..  ...::||   |.|  :||::|::.|||.|
Mouse   235 ERPIIFYAVCYMMVSLIFFI-GFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTM 298

  Fly   408 ASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYV 472
            |.|:|||||:.||||||..|||:|||.|.:..||.:||.||...::.:|.::.::||.|.|:|:|
Mouse   299 AGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFV 363

  Fly   473 GNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGI 537
            |..:.|.|:.||||||.:|:|:|.:.|:||.:||.|:|..|..:     ....|||.|.|||||:
Mouse   364 GLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLE-----KENQDKLVKFMIRIGV 423

  Fly   538 FSVLYTVPATIVIGCYLYEAAYFEDW--------IKALACPCAQVKGPGKKPLYSVLMLKYFMAL 594
            ||:||.||..:|||||.||.||...|        .:....||........:|...:.::||.|||
Mouse   424 FSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMAL 488

  Fly   595 AVGITSGVWIWSGKTLESWRRFW------------RRLLGAPDRTGANQALIKQ-RPPIPHPYAG 646
            .|||.|..|:.|.||...|..|:            |::|..||..   |:|::. ..||.....|
Mouse   489 IVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFA---QSLLRDPNTPIIRKSRG 550

  Fly   647 S---GMGMPVGSAAGSLLATPYTQAGGA-SVASTSHHHLH 682
            :   |......|...:::....::||.. |..|:.|..||
Mouse   551 TSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLH 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	50/131 (38%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	139/337 (41%)
		TM helix 1	316..341	CDD:320163	11/24 (46%)
		TM helix 2	350..371	CDD:320163	9/20 (45%)
		TM helix 3	396..422	CDD:320163	15/25 (60%)
		TM helix 4	439..455	CDD:320163	6/15 (40%)
		TM helix 5	477..506	CDD:320163	14/28 (50%)
		TM helix 6	531..558	CDD:320163	18/26 (69%)
		TM helix 7	579..604	CDD:320163	10/24 (42%)
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	51/154 (33%)
		7tmF_FZD3	192..512	CDD:320161	139/325 (43%)
		TM helix 1	201..226	CDD:320161	11/24 (46%)
		TM helix 2	235..256	CDD:320161	9/21 (43%)
		TM helix 3	287..313	CDD:320161	15/25 (60%)
		TM helix 4	330..352	CDD:320161	7/21 (33%)
		TM helix 5	366..391	CDD:320161	11/24 (46%)
		TM helix 6	419..444	CDD:320161	17/24 (71%)
		TM helix 7	473..498	CDD:320161	10/24 (42%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..666		12/53 (23%)