Protein Alignment fz2 and Fzd1

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_067432.2
• Gene: Fzd1 / 14362
• MGIID: 1196625
• Length: 642
• Species: Mus musculus
• Alignment Length: 658
• Identity: 279/658 - (42%)
• Similarity: 362/658 - (55%)
• Gaps: 127/658 - (19%)

  Fly    12 GLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAP-------------GYGVPVIPKDPNLR 63
            ||:|||....|  ||...........:.|.|..|.|.|             |..:|     .:..
Mouse    53 GLLLLLWLLEA--PLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIP-----DHGY 110

  Fly    64 CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--L 126
            |:.|:||:|..|.||.|..||.:.|..|::||||||||:|||:::||.:|||||||||.|:|  |
Mouse   111 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL 175

  Fly   127 EDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGS 191
            |   :.||.|||:|||||.||..:|.::.|:||:.:.||..|:|| ...||:
Mouse   176 E---QALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG-AGELCV------------- 223

  Fly   192 SGGSGGSGSGSGSGG-------KRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKAS 249
              |...|..|:.:..       ...|.|.|....|..|.:|:..    ||:.|
Mouse   224 --GQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVE----RGKFS------------ 270

  Fly   250 GKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP------F 308
               |..:.|.|.                        |:|   ....|..:||.||:..      :
Mouse   271 ---CPRALRVPS------------------------YLN---YHFLGEKDCGAPCEPTKVYGLMY 305

  Fly   309 FSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFL 373
            |..:|..|:..||.:||.||..|||.|:.|:::|..||.||||||:|||.||..|||.|:: .||
Mouse   306 FGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIA-GFL 369

  Fly   374 QNEEIAC------DGLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEA 432
            ..:.:.|      ||.......|....||::|::.|||.|||||||||||.|||||||:|||:||
Mouse   370 LEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEA 434

  Fly   433 ITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTT 497
            |..:|||||||||.:|.::::.:|.|..||||.:.|:|:||..|.|.|:.||||||||||.|||:
Mouse   435 IEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTS 499

  Fly   498 FLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFED 562
            ||:||||||||||:::|..     |.|.:||||||:|||:|||||||||||||.||.||.|:.:.
Mouse   500 FLLAGFVSLFRIRTIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQ 559

  Fly   563 W--------IKALACPCAQVKG-------PGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLES 612
            |        .|:.|.||..::|       |...|.::|.|:||.|.|.||||||.||||||||.|
Mouse   560 WERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNS 624

  Fly   613 WRRFWRRL 620
            ||:|:.||
Mouse   625 WRKFYTRL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	62/120 (52%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	178/337 (53%)
		TM helix 1	316..341	CDD:320163	12/24 (50%)
		TM helix 2	350..371	CDD:320163	13/20 (65%)
		TM helix 3	396..422	CDD:320163	18/25 (72%)
		TM helix 4	439..455	CDD:320163	8/15 (53%)
		TM helix 5	477..506	CDD:320163	21/28 (75%)
		TM helix 6	531..558	CDD:320163	22/26 (85%)
		TM helix 7	579..604	CDD:320163	13/24 (54%)
Fzd1	NP_067432.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..45
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..99		5/22 (23%)
		CRD_FZ1	107..233	CDD:143574	65/144 (45%)
		7tmF_FZD1	294..641	CDD:320375	182/345 (53%)
		TM helix 1	313..338	CDD:320375	12/24 (50%)
		TM helix 2	347..368	CDD:320375	13/21 (62%)
		TM helix 3	398..424	CDD:320375	18/25 (72%)
		TM helix 4	441..457	CDD:320375	8/15 (53%)
		TM helix 5	479..508	CDD:320375	21/28 (75%)
		TM helix 6	528..555	CDD:320375	22/26 (85%)
		TM helix 7	591..616	CDD:320375	13/24 (54%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		3/4 (75%)
		PDZ-binding	640..642