Protein Alignment fz2 and fz4

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: XP_319612.2
• Gene: fz4 / 1279837
• VectorBaseID: AGAMI1_009142
• Length: 616
• Species: Anopheles gambiae
• Alignment Length: 711
• Identity: 192/711 - (27%)
• Similarity: 275/711 - (38%)
• Gaps: 202/711 - (28%)

  Fly    64 CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLED 128
            ||.|.|.:|||||||.||.||.:.||.|.:|...:..|:||::..||..||||||:.|.|:|...
Mosquito    34 CEPIRIELCRGIGYNETSLPNIVGHELQSDANFTLQTFFPLIQFGCSKQLKFFLCATYVPMCTPK 98

  Fly   129 YHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSG 193
            ...|:..|||:|...::.|.||:|.:.|.||..:.|...|...:.:::||:.|
Mosquito    99 VSMPIGPCRSLCNTVKNRCHPILQGFGFPWPSALDCNRFPEENNHEHMCMQGP------------ 151

  Fly   194 GSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQ---NPQGEKASGKECSC 255
                                   |..|.|....:....|:|....|..   |..|      .|:.
Mosquito   152 -----------------------GEPAEGEVLVSDRPSCQGLQRSNLYVQLNRSG------RCAP 187

  Fly   256 SCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLW 320
            .|.:.::|   ||                                           :||.||.:|
Mosquito   188 LCEADIMF---EQ-------------------------------------------NEKHFAEVW 206

  Fly   321 IALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD---- 381
            :..||.....:.::.....|:.|:|:.....|:| :|.|  :|.||:..|........||.
Mosquito   207 LTSWSVAALGTAIVATLCLILSTKRWDKSLMPLV-ISHC--LVTVGWAVRWLAGRNATACGYDPQ 268

  Fly   382 ----GLLLRES-STGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAI-------- 433
                .|||.:. ||.|  |...|||.|:||:::::||.||...|..:.....|.:..
Mosquito   269 LPGVALLLTDGLSTAP--CAATFLLRYYFGLSAAVWWAILCLRWSKSVRRLLGTDLTSPADLHAE 331

  Fly   434 ---TKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIG 495
               :.|...|.||||.||.|.:|.||:...||.|.:.|.|::||.:...|.|||:.||....|||
Mosquito   332 KPNSSHDTLFQLAAWGIPAVLTVIVLVARLVDADELFGSCFIGNQSDKALLTFVIVPLLSSWVIG 396

  Fly   496 TTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRI---GIFSVLYTVPATIVIGCYLYEA 557
            :.:|   |.:..|.||           .....:..|.:.|   |.|..:|.||:..::....||.
Mosquito   397 SGYL---FTAYLRKRS-----------AAPPLVHNLPVHIHGMGKFLFIYAVPSAALLMLMFYEY 447

  Fly   558 AYFEDWI----KALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWR 618
            |..|:|:    .:|..|.    .|.:.||:..| |:.|:.|.||:.:..|           ....
Mosquito   448 ACRENWLHLPHPSLDSPL----HPSRAPLWPFL-LRAFIELLVGVLASAW-----------AVGP 496

  Fly   619 RLLG---APDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVASTSHHH 680
            |::|   ..|.||.               .|.|.||.||...|.:        |..|..|
Mosquito   497 RIVGLCRGRDGTGG---------------GGVGGGMGVGGRGGGV--------GKLSAGS----- 533

  Fly   681 LHHHVLKQPAASHVXHGESGGASTMGG-GGGGGSTLGGGTLGHGTAMSSST---VGMGPLP 737
                |.|||.         ||...:|| .||..||.  .|..:.|....::   |.:|.||
Mosquito   534 ----VYKQPV---------GGLPKLGGFAGGAPSTY--STASYQTVCPQNSLVAVSIGKLP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	49/117 (42%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	96/337 (28%)
		TM helix 1	316..341	CDD:320163	5/24 (21%)
		TM helix 2	350..371	CDD:320163	7/20 (35%)
		TM helix 3	396..422	CDD:320163	11/25 (44%)
		TM helix 4	439..455	CDD:320163	9/15 (60%)
		TM helix 5	477..506	CDD:320163	11/28 (39%)
		TM helix 6	531..558	CDD:320163	9/29 (31%)
		TM helix 7	579..604	CDD:320163	8/24 (33%)
fz4	XP_319612.2	None