Protein Alignment fz2 and smo

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: XP_061511627.1
• Gene: smo / 1275473
• VectorBaseID: AGAMI1_003428
• Length: 1155
• Species: Anopheles gambiae
• Alignment Length: 963
• Identity: 211/963 - (21%)
• Similarity: 339/963 - (35%)
• Gaps: 362/963 - (37%)

  Fly    49 PGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEI-KCSPD 112
            ||...|:    .:.:|...|:|. ..|..::|      :..:|:|...::||:..|..: ||...
Mosquito    77 PGKCEPI----KHRQCLHSTLPY-SSISLDLT------DSYSQEEMHTKLHQYNALKSVPKCWAV 130

  Fly   113 LKFFLCSMYTPICL----ED--YHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHG 171
            ::.|||:::||.|.    :|  |...|.:|:...|..|     |:...|| :||.:.|.
Mosquito   131 IQPFLCAVFTPKCEKINGQDMVYLPTLEMCKLTLEPCR-----ILHNTSF-FPEFLKCN------ 183

  Fly   172 DPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRN 236
              :.|   .||
Mosquito   184 --ETL---YPS------------------------------------------------------ 189

  Fly   237 SKNCQNPQGEK----ASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGV 297
              .|.|...|:    |||:     |:.||:          .:.:|..::..             :
Mosquito   190 --KCNNDVREEMKFNASGQ-----CQKPLV----------AADLPANYYKE-------------I 224

  Fly   298 PNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACYF 361
            ..||:.||.|.:::.|.......:|..:.:|....|.||.||.||.:.. |||...|.:::.|:.
Mosquito   225 DGCGVQCKDPLYTDHEHRQIHKLVAWGASICLAFNLFTLATFAIDWQNANKYPAMVIFYINFCFA 289

  Fly   362 MVAVGYLSRNFLQ--NEEIAC--DGLL-LRESSTGPH-SCTLVFLLTYFFGMASSIWWVILSFTW 420
            :..:|:|:: |..  .|:|.|  ||.| ..|.|.|.: ||.:||:|.|:|.:|:.:|:||.::.|
Mosquito   290 VSCLGWLAQ-FTPGGREDIVCRKDGTLRTSEPSAGENLSCIVVFILVYYFLIAAMVWFVIFTYVW 353

  Fly   421 ---FLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKT 482
               |.|.|..  .:.|.|...||||.||.:|.|.::.::.||.:||:..:|||:||..|......
Mosquito   354 HMSFKAIGKI--QDRIDKKGSYFHLIAWSLPLVLTITIMALSEIDGNSTVGICFVGYQNHPIRGA 416

  Fly   483 FVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGI---FSVLYTV 544
            |:|.|:...|::|..||..|.::|.|:|...:|   :.:...:.|:.:.::|:|:   |:.::.|
Mosquito   417 FLLGPVLCVLLVGGYFLGRGLLTLIRLRISSRQ---IISARASKKIHQTIVRMGVCTTFTFIFIV 478

  Fly   545 PATIVIGCYLYEAAYFEDWIKAL------------------ACPCAQVKGPGKKPLYSVLMLKYF 591
            ....   |:::|..:...|.:||                  .|...|      :|..::|.|...
Mosquito   479 ATAF---CHVHEFRHSAAWAEALRGFLVCQIVAAFNDDVTNGCRYEQ------RPSVAILQLHLI 534

  Fly   592 MALAVGITSGVWIWSGKTLESWRRFWRRLLGA----PDRTGAN----QALIKQR----------- 637
            ...|.||....|:|:..|||||.|::||..|.    |.:...:    ||..|::
Mosquito   535 CLFASGIVMSSWVWTNSTLESWGRYFRRRFGTDIDEPVKLQKHKVIAQAFAKRKEFQNQGRLSIS 599

  Fly   638 ------PPIPHPYAGSGMGMPVGSAAGS-------------LLATPYTQAGGASVASTSH----- 678
                  .|:       |:...:.||.||             .:.......|.|:  |:||
Mosquito   600 FHNSHTDPV-------GLKFDITSAIGSHDFSSTWANNLPRFVNRRCALTGAAT--SSSHDPRKN 655

  Fly   679 ----------HHL-----------------------------------------HHHVLKQPAAS 692
                      .|:                                         |.|..:|....
Mosquito   656 SVDSEISFSVRHVSVESRRNSIDSQVSVKIAEVKTKVASRSSRGTVVVGATGSKHGHKSRQSRRR 720

  Fly   693 H----VXHGESGG---------------ASTMGGGGGGGSTLGG-GTLGHGTAMSSSTVG----- 732
            |    . .|...|               |.....|.|.|...|| ||.|.|:....:.:|
Mosquito   721 HDFATTATGRRYGRKESSTSVESQIVTAAIQKSAGSGAGRYAGGAGTFGAGSMQRRTGIGALDAH 785

  Fly   733 --------------------------------------------MGPLPGTLMHG---ASGGGVG 750
                                                        |....|:...|   |.|||||
Mosquito   786 QINDLISNGKLLLPFLQGQGLTTSEDDNVSVGSFKLHDSKFDIIMKKFEGSSRIGTSCAGGGGVG 850

  Fly   751 GGNPGNVYGNGNNGVGGQNTAPGSVIDSRAVSVVVTLPGGPGAQHPGQALSDY 803
            ||..|  .|:|:.|:.| .:.||:           |:.||.|    |..:.:|
Mosquito   851 GGGVG--VGSGSGGMNG-TSGPGT-----------TVGGGGG----GCRIEEY 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	31/125 (25%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	101/341 (30%)
		TM helix 1	316..341	CDD:320163	7/24 (29%)
		TM helix 2	350..371	CDD:320163	4/20 (20%)
		TM helix 3	396..422	CDD:320163	10/28 (36%)
		TM helix 4	439..455	CDD:320163	8/15 (53%)
		TM helix 5	477..506	CDD:320163	8/28 (29%)
		TM helix 6	531..558	CDD:320163	6/29 (21%)
		TM helix 7	579..604	CDD:320163	6/24 (25%)
smo	XP_061511627.1	None