Protein Alignment fz2 and fz2

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: XP_061518617.1
• Gene: fz2 / 1272596
• VectorBaseID: AGAMI1_002571
• Length: 687
• Species: Anopheles gambiae
• Alignment Length: 693
• Identity: 492/693 - (70%)
• Similarity: 554/693 - (79%)
• Gaps: 32/693 - (4%)

  Fly     5 RLKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITI 69
            |..|.:|.::||:.|..|:...||.               .||.|  .||.:|||||.|||||||
Mosquito    24 RCAVSVLPILLLMISGVAECSYHSG---------------VSPMP--HVPAVPKDPNSRCEEITI 71

  Fly    70 PMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLP 134
            |||||||||:||||||||||||:|||||||||||||||||||||||||||||||||:||||||||
Mosquito    72 PMCRGIGYNLTSFPNEMNHETQEEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICIEDYHKPLP 136

  Fly   135 VCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSG 199
            ||||||||||:||||||:.|||.||||||||:||:.||.||||||.|...|.|....:|||.|.|
Mosquito   137 VCRSVCERARAGCAPIMESYSFNWPERMACENLPVSGDSDNLCMEMPREEEHGEDRGAGGSSGGG 201

  Fly   200 SG-SGSGGK--RKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPL 261
            || ||..||  ||..| ||||..:||  |:.....|:|:||||||||.||:.  |||.|.||.||
Mosquito   202 SGSSGHSGKPTRKSHG-GSGGQSSGG--GNQQNNKCKGKNSKNCQNPPGERT--KECMCRCREPL 261

  Fly   262 IFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSG 326
            :.||:|     .|...::||......|.:|:|:..|.||.|||:|.||:.:||||||:|||||||
Mosquito   262 VTLGRE-----SSTTTLLHHHGSLSSNQSVERVGDVQNCAIPCRGAFFTQEEKDFAGIWIALWSG 321

  Fly   327 LCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTG 391
            ||..|||||||||:|||||||||||||||||||||:|:.|||:|.||.::||||||..::..|||
Mosquito   322 LCGISTLMTLTTFLIDTERFKYPERPIVFLSACYFIVSCGYLTRIFLGHDEIACDGKSIKYPSTG 386

  Fly   392 PHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVL 456
            ..|||::|::.|||||||||||||||||||||||||||||||:|||||||||||||||||:|:||
Mosquito   387 QSSCTMIFIMIYFFGMASSIWWVILSFTWFLAAGLKWGNEAISKHSQYFHLAAWLIPTVQTVSVL 451

  Fly   457 LLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGA 521
            |..||||||:.|||||||.:.::||.|||||||:|||:||||||||||||||||||||||||:||
Mosquito   452 LRPAVDGDPVAGICYVGNTSVENLKNFVLAPLFMYLVVGTTFLMAGFVSLFRIRSVIKQQGGIGA 516

  Fly   522 GVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVL 586
            |.|||||||||||||||||||||||||||||:||||:|||||:..|.|||....|..:|||||||
Mosquito   517 GSKADKLEKLMIRIGIFSVLYTVPATIVIGCHLYEASYFEDWMTGLTCPCKVAPGLRQKPLYSVL 581

  Fly   587 MLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGM 651
            |||||||||||||||||||||||::||||.||||.|:||.|||.|.|||.|||:|.|||.||:|:
Mosquito   582 MLKYFMALAVGITSGVWIWSGKTVDSWRRLWRRLFGSPDPTGAGQVLIKPRPPLPQPYATSGIGV 646

  Fly   652 PVGSAAGSLLATPYTQAGGASVASTSHHHLHHHVLKQPAASHV 694
            | ||||.|||||||||..| |||||||||||||||||...|||
Mosquito   647 P-GSAAASLLATPYTQTVG-SVASTSHHHLHHHVLKQAPLSHV 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	106/118 (90%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	248/310 (80%)
		TM helix 1	316..341	CDD:320163	21/24 (88%)
		TM helix 2	350..371	CDD:320163	16/20 (80%)
		TM helix 3	396..422	CDD:320163	20/25 (80%)
		TM helix 4	439..455	CDD:320163	14/15 (93%)
		TM helix 5	477..506	CDD:320163	22/28 (79%)
		TM helix 6	531..558	CDD:320163	25/26 (96%)
		TM helix 7	579..604	CDD:320163	23/24 (96%)
fz2	XP_061518617.1	None