| Sequence 1: | NP_001262037.1 | Gene: | fz2 / 40090 | FlyBaseID: | FBgn0016797 | Length: | 806 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_009128.1 | Gene: | FZD10 / 11211 | HGNCID: | 4039 | Length: | 581 | Species: | Homo sapiens |
| Alignment Length: | 653 | Identity: | 271/653 - (41%) |
|---|---|---|---|
| Similarity: | 350/653 - (53%) | Gaps: | 153/653 - (23%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 11 LGLVL-LLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRG 74
Fly 75 IGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSV 139
Fly 140 CERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSG----- 199
Fly 200 -----SGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRS 259
Fly 260 PLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAG-VPNCGIPCKGPFFSNDEKDFAGLWIAL 323
Fly 324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRES 388
Fly 389 -----------STGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHL 442
Fly 443 AAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLF 507
Fly 508 RIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------- 563
Fly 564 -----IKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623
Fly 624 PDR 626 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz2 | NP_001262037.1 | CRD_FZ5_like | 63..182 | CDD:143565 | 62/118 (53%) |
| Frizzled | 308..618 | CDD:279827 | 169/334 (51%) | ||
| FZD10 | NP_009128.1 | CRD_FZ10 | 30..156 | CDD:143571 | 66/141 (47%) |
| 7tmF_FZD10 | 217..535 | CDD:320165 | 169/334 (51%) | ||
| TM helix 1 | 226..251 | CDD:320165 | 12/24 (50%) | ||
| TM helix 2 | 260..281 | CDD:320165 | 13/20 (65%) | ||
| TM helix 3 | 310..336 | CDD:320165 | 18/25 (72%) | ||
| TM helix 4 | 353..369 | CDD:320165 | 10/15 (67%) | ||
| TM helix 5 | 391..420 | CDD:320165 | 16/28 (57%) | ||
| TM helix 6 | 440..467 | CDD:320165 | 21/26 (81%) | ||
| TM helix 7 | 497..522 | CDD:320165 | 12/24 (50%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 526..531 | 3/4 (75%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 560..581 | ||||
| PDZ-binding | 579..581 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.820 | |||||