Protein Alignment fz2 and fzd4

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: XP_002936589.1
• Gene: fzd4 / 100497693
• XenbaseID: XB-GENE-478210
• Length: 523
• Species: Xenopus tropicalis
• Alignment Length: 640
• Identity: 241/640 - (37%)
• Similarity: 332/640 - (51%)
• Gaps: 146/640 - (22%)

  Fly     8 VLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMC 72
            |..|.|.|.|..|                 :.||      ..|:|     .:...||:.|.|.||
 Frog     3 VRALALCLPLLGC-----------------LVGH------IAGFG-----DEEERRCDPIRISMC 39

  Fly    73 RGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCR 137
            :.:|||:|..||.:.||.|.:|.|::..|.||::..||..|:|||||:|.|:|.|..:.|:..|.
 Frog    40 QNLGYNVTKMPNLVGHELQADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCG 104

  Fly   138 SVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGS 202
            .:|...:..|.|:::::.|.|||.:.|...|...|.:::|||.|...|.
 Frog   105 GMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDDEV---------------- 153

  Fly   203 GSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKE 267
                                        |.   :||....| ||       .|:...|    ..:
 Frog   154 ----------------------------PV---HSKTPVLP-GE-------DCNSFGP----NSD 175

  Fly   268 QLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIALWSGLCFC 330
            |              :.|     |:|..   ||.:.|  ....:|...|:|..:|:|:|:.|||.
 Frog   176 Q--------------YTW-----VKRSM---NCVLKCGYDSGLYSRLSKEFTDIWMAVWASLCFI 218

  Fly   331 STLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRE-- 387
            ||..|:.||:||:.||.||||||:|||.||.:.::.|:.|..:..|.|:||      .:|::|
 Frog   219 STAFTVLTFLIDSSRFCYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGL 283

  Fly   388 SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQS 452
            .:||   |.::|||.||||||||||||||:.|||||||||||:|||..||.|||:|||.||.|::
 Frog   284 KNTG---CAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKT 345

  Fly   453 VAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQG 517
            :.:|::..||.|.:.|:|||||.|.|.|..||:||||.||||||.|:.||.|:||:|||.:::.
 Frog   346 IVILIMRLVDADELTGLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD- 409

  Fly   518 GVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPL 582
                |.|.||||:||::||:||||||||||.||.||.||   ..:|        ...:.......
 Frog   410 ----GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--------NVFRYTADDSN 459

  Fly   583 YSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGANQALIKQR 637
            .:|.||..||:|.||||||:||||.|||.:|::...||:        |...:|::
 Frog   460 MAVEMLNIFMSLLVGITSGMWIWSAKTLHTWQKCTNRLV--------NSGKVKRK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	47/118 (40%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	163/318 (51%)
		TM helix 1	316..341	CDD:320163	12/24 (50%)
		TM helix 2	350..371	CDD:320163	10/20 (50%)
		TM helix 3	396..422	CDD:320163	19/25 (76%)
		TM helix 4	439..455	CDD:320163	9/15 (60%)
		TM helix 5	477..506	CDD:320163	18/28 (64%)
		TM helix 6	531..558	CDD:320163	20/26 (77%)
		TM helix 7	579..604	CDD:320163	12/24 (50%)
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	48/124 (39%)
		7tmF_FZD4	195..495	CDD:320166	163/318 (51%)
		TM helix 1	204..229	CDD:320166	12/24 (50%)
		TM helix 2	238..259	CDD:320166	10/20 (50%)
		TM helix 3	289..315	CDD:320166	19/25 (76%)
		TM helix 4	332..348	CDD:320166	9/15 (60%)
		TM helix 5	370..399	CDD:320166	18/28 (64%)
		TM helix 6	419..446	CDD:320166	20/29 (69%)
		TM helix 7	456..481	CDD:320166	12/24 (50%)