Protein Alignment fz2 and smo

DIOPT Version :9

• Sequence 1: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_002931911.2
• Gene: smo / 100491644
• XenbaseID: XB-GENE-487420
• Length: 815
• Species: Xenopus tropicalis
• Alignment Length: 603
• Identity: 153/603 - (25%)
• Similarity: 258/603 - (42%)
• Gaps: 156/603 - (25%)

  Fly    64 CEEITIPMCRG--IGYNMTSFPNEMNHETQDEAGLEVHQ---FW------PLVEIKCSPDLKFFL 117
            ||.:...:|.|  :.|.:||.....:..||:    |:|.   .|      |    :|...::..|
 Frog    43 CEPLKYNVCLGSVLPYALTSTVLAEDSSTQE----EIHDKLLLWSGLRNAP----RCWDAIRPLL 99

  Fly   118 CSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMAC--EHLPLHGDPDNLCMEQ 180
            |::|.|.| |.....|| .:|:|:..|..||.:.::..  ||:.:.|  :|.|      :.|..:
 Frog   100 CAVYMPKC-EGGKVELP-SQSLCQTTRVPCAIVARERG--WPDFLKCTTDHFP------DGCSNE 154

  Fly   181 PSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQG 245
            ....:..|.|
 Frog   155 IQTVKFNSSG------------------------------------------------------- 164

  Fly   246 EKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFS 310
                      .|.:||:               ...:|..||.:        |..|||.|:.|.|:
 Frog   165 ----------QCEAPLV---------------RTDNPKSWYED--------VEGCGIQCQNPLFT 196

  Fly   311 NDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERF-KYPERPIVFLSACYFMVAVGYLSRNFLQ 374
            ..|.....::||::|.:....|..||.||:.|.:.. :||...:.:::||:|:.::|:|:: |:.
 Frog   197 KKEHREMHVYIAIFSSVTIFCTFFTLATFLSDWKNSNRYPAVILFYVNACFFVGSIGWLAQ-FMD 260

  Fly   375 --NEEIACDG---LLLRE-SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTW---FLAAGLKWGN 430
              .:||.|.|   :.|.| :|....||.::|::.|:..|:..||:|:|::.|   |.|.|..  :
 Frog   261 GARDEIVCRGDGTMRLGEPTSNETLSCVIIFVIVYYAMMSGVIWFVMLTYAWHTSFKALGTT--H 323

  Fly   431 EAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIG 495
            :.::..:.||||..|.||.|.:||:|.::.||||.:.|||:||..|..:...|||||:.:.|::|
 Frog   324 QPLSGKTSYFHLITWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYHYRAGFVLAPIGLVLIVG 388

  Fly   496 TTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYF 560
            ..||:.|.::||.|:|   ...|:.:...|.|:.:.|:|:|||..|......|..||:.|:....
 Frog   389 GYFLIRGVMTLFSIKS---NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQ 450

  Fly   561 EDWIKA----LAC--------------PCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSG 607
            .:|.::    :.|              |..::|   .:|...|..:..|.....||:...|:|:.
 Frog   451 AEWERSFREYVLCEANVTIAEQTNKPIPECEIK---NRPSLLVEKINLFAMFGTGISMSTWVWTK 512

  Fly   608 KTLESWRRFWRRLLGAPD 625
            .|:..|:|.|.|:||..|
 Frog   513 ATIIIWKRAWCRILGRSD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	33/130 (25%)
		Frizzled	308..618	CDD:279827	101/337 (30%)
smo	XP_002931911.2	CRD_SMO	39..169	CDD:143560	36/208 (17%)
		7tmF_SMO_homolog	193..523	CDD:320158	102/338 (30%)
		TM helix 1	202..227	CDD:320158	8/24 (33%)
		TM helix 2	237..258	CDD:320158	5/21 (24%)
		TM helix 3	288..314	CDD:320158	8/25 (32%)
		TM helix 4	332..348	CDD:320158	9/15 (60%)
		TM helix 5	370..399	CDD:320158	10/28 (36%)
		TM helix 6	421..448	CDD:320158	10/26 (38%)
		TM helix 7	484..509	CDD:320158	5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010