DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz2 and fzd9

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_004911821.1	Gene:	fzd9 / 100487936	XenbaseID:	XB-GENE-478317	Length:	587	Species:	Xenopus tropicalis

Alignment Length:	632	Identity:	260/632 - (41%)
Similarity:	342/632 - (54%)	Gaps:	110/632 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFF 116
            |:..:.:....:||.|.||||:|||||||..||.:.||:|:||..::.:|.||||..|...|:||
Frog    26 GLYDVERGREAKCEPIQIPMCQGIGYNMTRMPNYVGHESQEEAAAKLQEFAPLVEYGCHIHLRFF 90

  Fly   117 LCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQP 181
            |||:|.|:|.|.....:|.|:.:||.||..|||||:.:.:.|||.:.|:.||...||..||||.|
Frog    91 LCSLYAPMCTEQVSTSIPACKPMCEAARQKCAPIMESFQYVWPESLDCDRLPSKNDPHALCMEAP 155

  Fly   182 SYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGE 246
                  ...::|....:|.|......|....|   |||.|.||              .|.||  :
Frog   156 ------ENATNGDPPTNGHGMLPVAPRPPRPS---GSGIGISS--------------RCANP--D 195

  Fly   247 KASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSN 311
            |....|.|..|                                       .|.| ||....::|:
Frog   196 KFMYVERSGVC---------------------------------------APRC-IPGVDVYWSS 220

  Fly   312 DEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNE 376
            .:||||.:|:|.||||||.||..|:.||::..:||:|||:||:|||.||.:.:..:|.|......
Frog   221 GDKDFALVWMAAWSGLCFISTAFTVFTFLLHPQRFQYPEKPIIFLSMCYNVYSTAFLIRAAAGAP 285

  Fly   377 EIACD-----GLLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAIT 434
            .||||     ..|:||  .|:|   ||||||:.|:||||||:|||:|:.||||||..|||:|||.
Frog   286 SIACDREGGAPYLIREGLESSG---CTLVFLILYYFGMASSLWWVVLTLTWFLAASKKWGHEAIE 347

  Fly   435 KHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFL 499
            .|..|||||||.||.::::.:|.:..|.||.:.|:||||..:|..|..|||.||..|||.||:||
Frog   348 SHGSYFHLAAWGIPAIKTIIILTMRKVGGDELTGLCYVGGSDPSALTGFVLVPLSCYLVTGTSFL 412

  Fly   500 MAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW- 563
            :.|||:||.||.|:|.     .|...:||||||::||:||:|||||||.:|.|..||......|
Frog   413 LTGFVALFHIRRVMKT-----GGTNTEKLEKLMVKIGVFSILYTVPATCIIVCCFYERLNLAHWD 472

  Fly   564 IKALACPCAQVKG--------PGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRF--WR 618
            .:|....|..|.|        |...|..:|.|||.||:||||||||||:||.|||::|:..  .|
Frog   473 SRAREESCRTVPGSARPDCNLPHSIPSVAVFMLKIFMSLAVGITSGVWVWSSKTLQAWQGILCQR 537

  Fly   619 RLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPY 665
            ||:....||       :.:|.       .|:|:|.     ||.:.||
Frog   538 RLVEVGART-------RGKPQ-------GGLGVPC-----SLGSCPY 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	60/118 (51%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	163/327 (50%)
fzd9	XP_004911821.1	CRD_FZ	34..159	CDD:382974	61/130 (47%)
		7tmF_FZD9	216..535	CDD:320164	163/326 (50%)
		TM helix 1	225..250	CDD:320164	15/24 (63%)
		TM helix 2	259..280	CDD:320164	9/20 (45%)
		TM helix 3	309..335	CDD:320164	18/25 (72%)
		TM helix 4	352..368	CDD:320164	9/15 (60%)
		TM helix 5	390..420	CDD:320164	17/29 (59%)
		TM helix 6	439..466	CDD:320164	17/26 (65%)
		TM helix 7	496..521	CDD:320164	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920