DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz2 and Fzd7

DIOPT Version :9

Sequence 1:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001258114.1	Gene:	Fzd7 / 100360552	RGDID:	2321905	Length:	572	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	279/641 - (43%)
Similarity:	367/641 - (57%)	Gaps:	119/641 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKVLILGLVLLLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIP 70
            |..|:|.|:..|.:.....|.    ||..|:.:..||.                    |:.|:||
  Rat    15 LCALVLALLGALPTDTGAQPY----HGEKGISVPDHGF--------------------CQPISIP 55

  Fly    71 MCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPV 135
            :|..|.||.|..||.:.|..|::||||||||:|||:::|||:|:|||||||.|:|.. ..:.:|.
  Rat    56 LCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPP 119

  Fly   136 CRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGS 200
            |||:|||||.||..:|.::.|:||||:.||:.|:|| ...:|:                  |..:
  Rat   120 CRSLCERARQGCEALMNKFGFQWPERLRCENFPVHG-AGEICV------------------GQNT 165

  Fly   201 GSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNP-QGEKASGKECSCSCRSPLIFL 264
            ..|||             |||||..:..|.|..........:| .|........||
  Rat   166 SDGSG-------------GAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRWSFPFSC--------- 208

  Fly   265 GKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP-------FFSNDEKDFAGLWIA 322
                  .:|.::|    |:..|      |..|..:||.||: |       :|..:|:.||.||:.
  Rat   209 ------PRQLKVP----PYLGY------RFLGERDCGAPCE-PGRANGLMYFKEEERRFARLWVG 256

  Fly   323 LWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC------D 381
            :||.||..|||.|:.|:::|..||.||||||:|||.|||||||.::: .||..:...|      |
  Rat   257 VWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVA-GFLLEDRAVCVERFSDD 320

  Fly   382 GLLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWL 446
            |.......|....||::|::.|||||||||||||||.|||||||:|||:|||..:|||||||||.
  Rat   321 GYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWA 385

  Fly   447 IPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRS 511
            :|.|:::.:|.:..||||.:.|:||||..:.|.|:.||||||||||.|||:||:||||||||||:
  Rat   386 VPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRT 450

  Fly   512 VIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------IKALA 568
            ::|..     |.|.:||||||:|||:||||||||||||:.||.||.|:.|.|        .|:.|
  Rat   451 IMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYA 510

  Fly   569 CPCAQVKGPG----KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620
            .||.    ||    ..|.::|.|:||.|.:.||||:|.||||||||:|||||:.||
  Rat   511 VPCP----PGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	60/118 (51%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	180/327 (55%)
Fzd7	NP_001258114.1	CRD_FZ7	45..169	CDD:143575	63/163 (39%)
		7tmF_FZD7	241..571	CDD:320374	182/332 (55%)
		TM helix 1	251..275	CDD:320374	12/23 (52%)
		TM helix 2	284..305	CDD:320374	14/21 (67%)
		TM helix 3	335..357	CDD:320374	16/21 (76%)
		TM helix 4	378..394	CDD:320374	9/15 (60%)
		TM helix 5	416..439	CDD:320374	16/22 (73%)
		TM helix 6	470..492	CDD:320374	17/21 (81%)
		TM helix 7	521..546	CDD:320374	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810