Protein Alignment fz2 and fzd3

DIOPT Version :10

• Sequence 1: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001123382.1
• Gene: fzd3 / 100038082
• XenbaseID: XB-GENE-484322
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 730
• Identity: 230/730 - (31%)
• Similarity: 319/730 - (43%)
• Gaps: 164/730 - (22%)

  Fly    40 GHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPL 104
            ||.|.|                  ||.||:.||:.:.||.|..||.:||..|..|.|.:..|.|:
 Frog    21 GHSLFA------------------CEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPM 67

  Fly   105 VEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPL 169
            |.::||.|.:.|||::|.|:|:|.....|| ||.:|:||.:.|..:|:.:...|||.|.|...|.
 Frog    68 VNLECSRDFRPFLCALYAPVCMEYGRVTLP-CRKLCQRAYNECFKLMEMFGVPWPEEMECSRFPD 131

  Fly   170 HGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRG 234
            ..:|      .|...:....|.                                  .|...|...
 Frog   132 CDEP------YPRMVDISLSGD----------------------------------VTEETPLAV 156

  Fly   235 RNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPN 299
            :.......|:..|..                                |...|..|      ||.:
 Frog   157 QRDYGFWCPRELKID--------------------------------PDLGYSFL------GVRD 183

  Fly   300 CGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVA 364
            |..||...:|..:|..||..:|.:.|.:|..:||.|..||:||..||:||||||:|.:.||.||:
 Frog   184 CSPPCPHMYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS 248

  Fly   365 VGYLSRNFLQNEEIACDG-----LLLRESSTGPH--SCTLVFLLTYFFGMASSIWWVILSFTWFL 422
            :.:.. .||..:::||:|     ......:.|.|  :||::|::.|||.||.|:|||||:.||||
 Frog   249 LIFFI-GFLLEDKVACNGANPSQYKAATVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFL 312

  Fly   423 AAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAP 487
            ||..|||:|||.|.:..||.:||.||...::.:|.::.::||.|.|:|:||..:...|:.|||||
 Frog   313 AAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVQALRYFVLAP 377

  Fly   488 LFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGC 552
            |.:.:|:|.:.|:||.:||.|:|..|..:     ....|||.|.|||||:||:||.||..:||||
 Frog   378 LCLDVVVGVSLLLAGIISLNRVRIEIPLE-----KENQDKLVKFMIRIGVFSILYLVPLLVVIGC 437

  Fly   553 YLYEAAYFEDW--------IKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKT 609
            |.||.||...|        .|....||........:|...:.::||.|||.|||.|..|:.|.||
 Frog   438 YFYEQAYRGVWETTWVQERCKEYHIPCPYKVTQTSRPDLILFLMKYLMALVVGIPSVFWVGSKKT 502

  Fly   610 LESWRRFWRRLLGAPDRTGANQA-LIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYT----QAG 669
            ...|..|:.   |...:.|.|:: .:.|.|..                |.|||..|.|    ::.
 Frog   503 CFEWASFFH---GRKKKAGVNESRQVLQEPDF----------------AQSLLRDPNTPIVRKSR 548

  Fly   670 GASVASTSHH-----------------HLHHHVLKQPAASHVXHGESGGASTMGGGGGGGSTLGG 717
            |.|...||.|                 .:|..|.....:   .|....|..|.....|....|..
 Frog   549 GTSTQGTSTHASSTQLAMLDDQRSKAGSVHSKVSSYHGS---LHRSRDGRYTPCSYRGMEERLPH 610

  Fly   718 GTLGHGTAMS--SST 730
            |:|.|.|..|  |||
 Frog   611 GSLSHLTDHSRHSST 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	45/118 (38%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	136/325 (42%)
		TM helix 1	316..341	CDD:320163	10/24 (42%)
		TM helix 2	350..371	CDD:320163	9/20 (45%)
		TM helix 3	396..422	CDD:320163	15/25 (60%)
		TM helix 4	439..455	CDD:320163	6/15 (40%)
		TM helix 5	477..506	CDD:320163	12/28 (43%)
		TM helix 6	531..558	CDD:320163	18/26 (69%)
		TM helix 7	579..604	CDD:320163	10/24 (42%)
fzd3	NP_001123382.1	CRD_FZ3	23..149	CDD:143558	49/184 (27%)
		7tmF_FZD3	191..511	CDD:320161	136/325 (42%)
		TM helix 1	200..225	CDD:320161	10/24 (42%)
		TM helix 2	234..255	CDD:320161	9/21 (43%)
		TM helix 3	286..312	CDD:320161	15/25 (60%)
		TM helix 4	329..351	CDD:320161	7/21 (33%)
		TM helix 5	365..390	CDD:320161	9/24 (38%)
		TM helix 6	418..443	CDD:320161	17/24 (71%)
		TM helix 7	472..497	CDD:320161	10/24 (42%)