DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gem2 and Gemin2

DIOPT Version :9

Sequence 1:	NP_001262034.1	Gene:	Gem2 / 40087	FlyBaseID:	FBgn0036850	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_079932.2	Gene:	Gemin2 / 66603	MGIID:	1913853	Length:	269	Species:	Mus musculus

Alignment Length:	261	Identity:	75/261 - (28%)
Similarity:	112/261 - (42%)	Gaps:	38/261 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QLQALEICEPDSSFDPQKPPESGEEYLMHMFYERKRCPAVVTKR--SSKI-RNNTGNTTLEMLDN 72
            :|..:|.|:....|||..||.:.:|||..:..|..:||.||..:  ..|: |..:.|.:|....
Mouse    16 RLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQ- 79

  Fly    73 PELPPFKCLLPTPEWRDEQVKSFQAARSQVLVLRKELANNNYDQSGEPPLTSDQEKWKEFCRNQQ 137
               |..:...||.:|:.:||..|...|..|...|....:...|.:...|.:.|:|.||:||..::
Mouse    80 ---PAPEGYSPTLQWQQQQVAHFSTVRQSVHKHRNHWKSQQLDSNVAMPKSEDEEGWKKFCLGER 141

  Fly   138 -------------------------PLLSTLLHLTQNDLELLLEMLSKWLQDPNTTVDLLHDVWL 177
                                     ||||.:..:.|..:..:||.||.|..:.:.|.:      |
Mouse   142 LCAEGATGPSTEESPGIDYVQVGFPPLLSIVSRMNQTTITSVLEYLSNWFGERDFTPE------L 200

  Fly   178 ARWLYATLVCLHLPLEPHVFSTLRYIARTCIHLRNQLKEDEVQRAAPYNLLLTLTVQVFAQNDFK 242
            .||.||.|.||..||.|...|.:|.:||.|..:|..:...:.:|....|||:.|..:.|.|.|..
Mouse   201 GRWFYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVGSKDDERVPALNLLICLVSRYFDQRDLA 265

  Fly   243 D 243
            |
Mouse   266 D 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gem2	NP_001262034.1	SIP1	18..239	CDD:282754	70/248 (28%)
Gemin2	NP_079932.2	SIP1	22..261	CDD:282754	70/248 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850814
Domainoid	1	1.000	100	1.000	Domainoid score	I7022
eggNOG	1	0.900	-	-		E1_28H7D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37827
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4888
Isobase	1	0.950	-	0	Normalized mean entropy	S3221
OMA	1	1.010	-	-		QHG55374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005780
OrthoInspector	1	1.000	-	-		oto93141
orthoMCL	1	0.900	-	-		OOG6_104791
Panther	1	1.100	-	-	LDO	PTHR12794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4058
SonicParanoid	1	1.000	-	-		X6261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740