DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNPYb and CNPY4

DIOPT Version :9

Sequence 1:	NP_649089.2	Gene:	CNPYb / 40084	FlyBaseID:	FBgn0036847	Length:	221	Species:	Drosophila melanogaster
Sequence 2:	NP_689968.1	Gene:	CNPY4 / 245812	HGNCID:	28631	Length:	248	Species:	Homo sapiens

Alignment Length:	221	Identity:	108/221 - (48%)
Similarity:	145/221 - (65%)	Gaps:	11/221 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GFVTLWVVLQL--------AGADSPEEEQGVRYANRCEACKILATELEARLGETGKSHDVIEIGY 64
            |.|.|.::|.|        ||....|::...|..::||.||:|:|||:|.|..||:|.:|:|:|.
Human     2 GPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQ 66

  Fly    65 SVDDVKPKKRTEYRRSELRLLESLENVCERVLEYNLHKERSDSTRFAKGMSQTFQTLHGLVDKGV 129
            .:|..|.|:...|..||.||.|:|||:|||:|:|::|.||..|.|:|||.|||..||.|||.|||
Human    67 VLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGV 131

  Fly   130 KVDLGIPYELWDKPPVEVTQMKTQCENLLEEYEETISEWYFKHQDEKSLKKHLCEDHVLKKKAER 194
            |||||||.||||:|.||||.:|.|||.:|||:|:.:.:|||.|| |:.|:..|||.||| ..||.
Human   132 KVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQ-EQPLQNFLCEGHVL-PAAET 194

  Fly   195 ECLKEQLAPPEAKKAKREKAKGDKEE 220
            .||:|.....|....: ||.:|::|:
Human   195 ACLQETWTGKEITDGE-EKTEGEEEQ 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNPYb	NP_649089.2	DUF3456	35..184	CDD:288766	84/148 (57%)
CNPY4	NP_689968.1	DUF3456	37..185	CDD:288766	84/148 (57%)
CNPY4	NP_689968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..248		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147271
Domainoid	1	1.000	187	1.000	Domainoid score	I3345
eggNOG	1	0.900	-	-		E1_KOG4052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15196
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3734
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1412562at2759
OrthoFinder	1	1.000	-	-		FOG0003994
OrthoInspector	1	1.000	-	-		oto89678
orthoMCL	1	0.900	-	-		OOG6_105615
Panther	1	1.100	-	-	LDO	PTHR15382
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3184
SonicParanoid	1	1.000	-	-		X2756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790