DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MESR6 and c5orf22

DIOPT Version :9

Sequence 1:	NP_001262033.1	Gene:	MESR6 / 40083	FlyBaseID:	FBgn0036846	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001011092.1	Gene:	c5orf22 / 496505	XenbaseID:	XB-GENE-985060	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	146/452 - (32%)
Similarity:	218/452 - (48%)	Gaps:	116/452 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 RHFQRIPVFIVDYHNDVLEFIYRCFATRHLPLQNNTLVHFDSHPDLVIPRHIAASSTYQKETMLN 156
            |.:..:||::|:.|:|||.||||...::|||:.|.:.:||||||||:||.::.|.:.:.||::.:
Frog    10 RKYNNLPVWVVEDHHDVLPFIYRAIGSKHLPVSNISFIHFDSHPDLLIPVNMPADTVFDKESLFS 74

  Fly   157 ELSIENWIMPTLYAEIENNVKGQIKKFYGHFNRVVWLKNSWCQQLPTGRHDFKVGQKD---DRIG 218
            ||||||||||.:||              |||::|:|:...|.||:..|||.|.|| ||   ..|.
Frog    75 ELSIENWIMPVVYA--------------GHFSQVIWIHPCWAQQIKEGRHCFLVG-KDKSTTTIR 124

  Fly   219 VDCPLDYFIADGNYCTTEDLQDAKSVELQV------HDADNE------------SLNPNEFLTEK 265
            |....|||::||.|...|.|:..||:.|.|      .:.|.|            .|..::.:.|.
Frog   125 VTSTDDYFLSDGLYVPEEQLESPKSLHLDVILLEPIREQDWEYKEKGETVAKKIKLEESDQVVEG 189

  Fly   266 DAKG---------------------------------------------------FVLDIDLDFF 279
            .:.|                                                   :|||||||||
Frog   190 SSSGIQSSTSESSEDGLMKPTYLNASTKTSNETCTLDSSSNLAKNIIQILEKGTVYVLDIDLDFF 254

  Fly   280 STSNPFLEIYKDADCYNQLKEIFHFE--SVEKVKKSGTATIADYLATAERRQTQLDALKTIFWHL 342
            |..|||.|:|.. |.|..|:|::.|:  ||..:::       :.:...|.|..||:.|:..|...
Frog   255 SVKNPFKEMYTQ-DEYKILQELYSFKRPSVHSLEE-------ELVDCVENRVHQLEDLEAAFADF 311

  Fly   343 EEERNFEGLEKPDETVVTPEVYA------KIVKLADQLQEKYPDDEIDWHLIFDSGSTTDNNGLP 401
            .|:.:       ||||   :.:|      .:|:|...|:.:.  :..|:.:|..:|.|.|...||
Frog   312 CEDDS-------DETV---QRWASNPGMNSLVQLVHSLKSRM--EAPDYEMIHQAGLTCDYAELP 364

  Fly   402 HHISIAEELETYFANFKRFLQRLPVPPVAITMAHSAQDDYCPQDQVAFIEECVLRLLKEVFG 463
            ||:|...|:|....:.|..|..|| .|..:|:|.|:.|||||.:||.:|:|.||.:|:.::|
Frog   365 HHVSTETEIEGLLQSVKNLLTCLP-KPTLVTLARSSLDDYCPSEQVDYIQEKVLDVLRSLYG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESR6	NP_001262033.1	UPF0489	99..279	CDD:289412	81/251 (32%)
c5orf22	NP_001011092.1	UPF0489	17..159	CDD:372236	69/156 (44%)
c5orf22	NP_001011092.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..207		2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10149
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3228
OMA	1	1.010	-	-		QHG59382
OrthoDB	1	1.010	-	-		D1501156at2759
OrthoFinder	1	1.000	-	-		FOG0007487
OrthoInspector	1	1.000	-	-		otm48895
Panther	1	1.100	-	-	LDO	PTHR13225
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5689
SonicParanoid	1	1.000	-	-		X5613
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110