DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and YVH1

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_012292.3	Gene:	YVH1 / 854844	SGDID:	S000001465	Length:	364	Species:	Saccharomyces cerevisiae

Alignment Length:	273	Identity:	74/273 - (27%)
Similarity:	116/273 - (42%)	Gaps:	77/273 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NYNEAPVEI--IPGLLFLGNATHSCDSEAL-KKYNIKYVLNVTPDLPNKFKESGDIKYL------ 265
            |.|....|:  |.|.::||......|...| .::||.::|:|.     ||:...:  ||
Yeast     4 NANSVDEEVTRILGGIYLGGIRPIIDHRPLGAEFNITHILSVI-----KFQVIPE--YLIRKGYT 61

  Fly   266 --QIPITDHYSQDLAIHFPDAIQFIEEARSASSV-----------------VLVHCLAGVSRSVT 311
              .|||.|....|:..:|.:..:||::....:.|                 |..||.||:|||||
Yeast    62 LKNIPIDDDDVTDVLQYFDETNRFIDQCLFPNEVEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVT 126

  Fly   312 VTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFE--------------SQLRLRPGS 362
            ..:||||:..||||:.|...|:.:||.|.||.:||:||..||              .|.:|:...
Yeast   127 FIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDFVDFDNPAYKQWKLKQSI 191

  Fly   363 RFSCSCIAPDCNCMQTTGFMATHLANATGVSPD--SGIEFDRWTPSD----TGLKXEQSGGK--- 418
            :...|               .:.|.:.:|:..|  |..:.|:.|.::    |.:: ::...|
Yeast   192 KLDPS---------------GSELVSNSGMFKDSESSQDLDKLTEAEKSKVTAVRCKKCRTKLAL 241

  Fly   419 --SFVL--PPSQE 427
              ||:.  |||:|
Yeast   242 STSFIAHDPPSKE 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723
		DSPc	215..353	CDD:238073	53/165 (32%)
		CDC14	<242..359	CDD:225297	48/155 (31%)
YVH1	NP_012292.3	DSP_fungal_YVH1	12..173	CDD:350368	54/167 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910