DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and DUSP16

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_085143.1	Gene:	DUSP16 / 80824	HGNCID:	17909	Length:	665	Species:	Homo sapiens

Alignment Length:	488	Identity:	121/488 - (24%)
Similarity:	209/488 - (42%)	Gaps:	107/488 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HETCSKEWLQSQLRSL---DSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLAS 67
            ||....:.:..:|.:|   .::.::|:|.|...||:.|||..|:|:....::.|||...|:.:..
Human     3 HEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITE 67

  Fly    68 TIK-SPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVV 131
            .|: |.:.|..|....|:   ::|:     ..:|::|...|     |..:::|..:|::....|.
Human    68 LIQHSAKHKVDIDCSQKV---VVYD-----QSSQDVASLSS-----DCFLTVLLGKLEKSFNSVH 119

  Fly   132 ALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDC 196
            .|..||..|.:.||..||.                       :|..:.|..| ..|...|
Human   120 LLAGGFAEFSRCFPGLCEG-----------------------KSTLVPTCIS-QPCLPVA----- 155

  Fly   197 ESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNV--TPDLPNKFKES 259
                           |..|..|:|. |:||......:.|.:::..|.||||.  |...|:...||
Human   156 ---------------NIGPTRILPN-LYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES 204

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
               .:|::|:.|.:.:.:......::.|||:|::::..||||||||:|||.|:.:||:|....:|
Human   205 ---HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMS 266

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANA 389
            |::|:..|::::|.:||||:|:.|||.:|.:::                              |.
Human   267 LDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK------------------------------NQ 301

  Fly   390 TGVS-PDSGIEFDRWTPSDTGLKXEQSGGKSFVLPPSQEVPFAAAATSPLPMCLAVNPDNMSPAS 453
            ||.| |.|.::.......:..:.....||:....|.|.  |.|.:|||.     |.....:.|||
Human   302 TGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSP--PCADSATSE-----AAGQRPVHPAS 359

  Fly   454 TTSSSTSTTTTAEAVSVVEMVQ--HRDQEMAEE 484
            ..|..:...:..|...:|:.:.  |...:..|:
Human   360 VPSVPSVQPSLLEDSPLVQALSGLHLSADRLED 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	35/143 (24%)
		DSPc	215..353	CDD:238073	51/139 (37%)
		CDC14	<242..359	CDD:225297	45/118 (38%)
DUSP16	NP_085143.1	DSP_MapKP	10..136	CDD:238723	35/138 (25%)
		DSPc	158..295	CDD:238073	51/140 (36%)
		CDC14	<207..300	CDD:225297	36/122 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..368		14/53 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..505
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940