DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and Dusp9

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_083628.3	Gene:	Dusp9 / 75590	MGIID:	2387107	Length:	452	Species:	Mus musculus

Alignment Length:	453	Identity:	152/453 - (33%)
Similarity:	223/453 - (49%)	Gaps:	89/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETCSKE--WLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTI 69
            |:.|:.  ||:.:|.| ....|:|||||....|..:.|.||:::.:||::||||..|.:.:.|.:
Mouse     2 ESLSRSCLWLRQELSS-PRPQLLLLDCRSRELYESARICGALSVALPSLMLRRLRRGSMSVRSLL 65

  Fly    70 KSPELKQRIQSGYKLCWFILYNGEGVPGQ-----------------------------------N 99
            ..|.|:....:.     .:||: :|..||                                   |
Mouse    66 PGPPLQPPPPAP-----VLLYD-QGSSGQCHREAAEAEAKAEPKAEAEAEPKAEAEAEPKAEAEN 124

  Fly   100 QEIAGAGSLAVA---------------------------------MDSIISILHRRLKQDGCRVV 131
            :..|.|.:.|.|                                 .||::.:|.::|:::|....
Mouse   125 EAEAKAEAKAEAKAEAKAEAKAEAKAEAKAEAKAEAKAEAKEEWDADSVLGVLLQKLREEGYPAY 189

  Fly   132 ALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTD--QLMGLRSLRISTTQSDSACSSSAESS 194
            .||.||:.|:...|..||   .:.|....|.....:.  .::||..|.:|:..||:...:..::.
Mouse   190 YLQGGFSKFQAECPHLCE---TSFSGRAGSGLGSMSSPVPVVGLGGLCLSSDFSDAESEADRDTL 251

  Fly   195 DCESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES 259
            .|...|.:............||:|:|. |:||:|..|.:.|:|.|..|:|:|||||:|||.|:::
Mouse   252 SCGLDSENTTSPPAGLLPPFPVQILPN-LYLGSARDSANLESLAKLGIRYILNVTPNLPNLFEKN 315

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
            ||..|.||||:||:||:|:..||:||.||:||.|.:..||||||||||||||||:||||....||
Mouse   316 GDFHYKQIPISDHWSQNLSQFFPEAIAFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLS 380

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL---RPGSRFSCSCIAPDCNCMQTTGFMAT 384
            ||||:.:|:.:|.::||||:||.|||.||..|||   |.|.|.|.   .|:........|..|
Mouse   381 LNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLGGKRSGGRGSG---GPESTVSDPPSFFTT 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	46/209 (22%)
		DSPc	215..353	CDD:238073	81/137 (59%)
		CDC14	<242..359	CDD:225297	74/119 (62%)
Dusp9	NP_083628.3	RHOD	5..206	CDD:294087	46/207 (22%)
		CDC14	251..410	CDD:225297	84/159 (53%)
		DSPc	272..409	CDD:238073	81/137 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3990
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3183
Isobase	1	0.950	-	0	Normalized mean entropy	S2795
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm44103
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890