Protein Alignment Mkp3 and Dusp16

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_569714.2
• Gene: Dusp16 / 70686
• MGIID: 1917936
• Length: 660
• Species: Mus musculus
• Alignment Length: 501
• Identity: 121/501 - (24%)
• Similarity: 209/501 - (41%)
• Gaps: 126/501 - (25%)

  Fly     6 HETCSKEWLQSQLRSL---DSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLAS 67
            ||....:.:...|.:|   .::.::|:|.|...||:.|||..|:|:....::.|||...|:.:..
Mouse     3 HEMIGTQIVTESLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITE 67

  Fly    68 TIK-SPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVV 131
            .|: |.:.|..|....|:   ::|        :|.....|||  :.|..:::|..:|::....|.
Mouse    68 LIQHSAKHKVDIDCNQKV---VVY--------DQSSQDVGSL--SSDCFLTVLLGKLERSFNSVH 119

  Fly   132 ALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDC 196
            .|..||..|.:.||..||.                       :|..:.|..| ..|...|
Mouse   120 LLAGGFAEFSRCFPGLCEG-----------------------KSTLVPTCIS-QPCLPVA----- 155

  Fly   197 ESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNV--TPDLPNKFKES 259
                           |..|..|:|. |:||......:.:.:::..|.||||.  |...|:...||
Mouse   156 ---------------NIGPTRILPN-LYLGCQRDVLNKDLMQQNGIGYVLNASNTCPKPDFIPES 204

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
               .:|::|:.|.:.:.:......::.|||:|::::..||:|||||:|||.|:.:||:|....:|
Mouse   205 ---HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLIHCLAGISRSATIAIAYIMKRMDMS 266

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANA 389
            |::|:..|::::|.:||||:||.||:.:|..:.                              |.
Mouse   267 LDEAYRFVKEKRPTISPNFNFMGQLMDYEKTIN------------------------------NQ 301

  Fly   390 TGVS-PDSGIEFDRWTPSDTGLKXEQSGGKSFVLPPSQEVPFAA-----AATSPLPMCL-----A 443
            ||:| |.|.::.         |. ::         ||:.||.|:     :|.|..|.|.     |
Mouse   302 TGMSGPKSKLKL---------LHLDK---------PSEPVPAASEGGWKSALSLSPPCANSTSEA 348

  Fly   444 VNPDNMSPASTTSSSTSTTTTAEAVSVVEMVQHRDQEMAEEDIITR 489
            .....:.|||..|...|....:..|..:..:|...:::.:...:.|
Mouse   349 SGQRLVHPASVPSLQPSLLEDSPLVQALSGLQLSSEKLEDSTKLKR 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	36/143 (25%)
		DSP_MKP_classII	215..352	CDD:350414	49/138 (36%)
Dusp16	NP_569714.2	DSP_MapKP	10..136	CDD:238723	36/138 (26%)
		PTP_DSP_cys	157..301	CDD:475123	50/177 (28%)