DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and Dusp6

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_080544.1	Gene:	Dusp6 / 67603	MGIID:	1914853	Length:	381	Species:	Mus musculus

Alignment Length:	351	Identity:	145/351 - (41%)
Similarity:	208/351 - (59%)	Gaps:	28/351 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR 77
            ||..|| .|.::.|:|:|||....|..|||..|:|:.||.|:||||..|.:.:.:.....|.:.|
Mouse    22 WLNEQL-ELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDR 85

  Fly    78 IQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQ 142
            ..........:||: |.....|:...|        :|::.:|.::||.:|||...|:.||:.|:.
Mouse    86 FTRRCGTDTVVLYD-ENSSDWNENTGG--------ESVLGLLLKKLKDEGCRAFYLEGGFSKFQA 141

  Fly   143 AFPEWCEDDNQTHSKEIESSRNVQTDQL--MGLRSLRISTTQSDSACSSSAESS---DCESSSHH 202
            .|...||.:       ::.|.:..:..|  :||..||||   |||  ||..||.   |..|::..
Mouse   142 EFALHCETN-------LDGSCSSSSPPLPVLGLGGLRIS---SDS--SSDIESDLDRDPNSATDS 194

  Fly   203 HHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQI 267
            ......::....||||:| .|:||.|..|.:.:.|:::.|||:|||||:|||.|:.:|:.||.||
Mouse   195 DGSPLSNSQPSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQI 258

  Fly   268 PITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMV 332
            ||:||:||:|:..||:||.||:|||..:..||||||||:|||||||:||||....||:|||:.:|
Mouse   259 PISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIV 323

  Fly   333 RDRKPDVSPNFHFMQQLLSFESQLRL 358
            :.:|.::||||:||.|||.||..|.|
Mouse   324 KMKKSNISPNFNFMGQLLDFERTLGL 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	43/134 (32%)
		DSPc	215..353	CDD:238073	79/137 (58%)
		CDC14	<242..359	CDD:225297	72/117 (62%)
Dusp6	NP_080544.1	DSP_MapKP	18..147	CDD:238723	43/134 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..203		7/28 (25%)
		CDC14	204..356	CDD:225297	83/147 (56%)
		DSPc	207..344	CDD:238073	79/137 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3990
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm44103
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.970