DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkp3 and Dusp10

DIOPT Version :9

Sequence 1:NP_001262031.1 Gene:Mkp3 / 40081 FlyBaseID:FBgn0036844 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_071302.2 Gene:Dusp10 / 63953 MGIID:1927070 Length:483 Species:Mus musculus


Alignment Length:358 Identity:118/358 - (32%)
Similarity:175/358 - (48%) Gaps:67/358 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 CSKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNL-CIPSIVLRRLAVGKI---DLASTI 69
            |||..|.||       ..:::|||...||::|||:|||:: |...|..|||..|||   ||.|..
Mouse   163 CSKSHLPSQ-------GPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCR 220

  Fly    70 KSPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQ 134
            :..:..:||.|..    .|:|:..  ..:...:..:..|.:.::|        ||::|...:.|:
Mouse   221 EGKDSFKRIFSKE----IIVYDEN--TNEPSRVTPSQPLHIVLES--------LKREGKEPLVLK 271

  Fly   135 DGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESS----- 194
            .|.::|:|.....|:     :|.:::..|.|               ....||.||....|     
Mouse   272 GGLSSFKQNHGNLCD-----NSLQLQECREV---------------GGGASAASSMLPQSVPTTP 316

  Fly   195 DCESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES 259
            |.|              |.....|:| .|||||...:.|.:.:::.||.||:|||..||....|.
Mouse   317 DIE--------------NAELTPILP-FLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEK 366

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLM-HTRGL 323
            |...|.::|.||...|:|..:|.:|.:|||||......:|:||.||||||.|:.:|||| ||| :
Mouse   367 GLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTR-M 430

  Fly   324 SLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL 356
            ::.||:..|:.::|.:|||.:||.|||.||..|
Mouse   431 TMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkp3NP_001262031.1 DSP_MapKP 8..148 CDD:238723 42/142 (30%)
DSPc 215..353 CDD:238073 61/138 (44%)
CDC14 <242..359 CDD:225297 55/116 (47%)
Dusp10NP_071302.2 DSP_MapKP 150..285 CDD:238723 42/142 (30%)
Interaction with MAP kinases. /evidence=ECO:0000250 200..216 7/15 (47%)
DSP_DUSP10 323..474 CDD:350415 64/143 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2281
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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