DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and SSH3

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_060327.3	Gene:	SSH3 / 54961	HGNCID:	30581	Length:	659	Species:	Homo sapiens

Alignment Length:	265	Identity:	67/265 - (25%)
Similarity:	107/265 - (40%)	Gaps:	32/265 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 LFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQF 287
            |:||:..::.:.|.|::..:.::||:..::.|.:.|.  ..|..:.:.|..|..|..|:.:..:|
Human   336 LYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPER--FTYHNVRLWDEESAQLLPHWKETHRF 398

  Fly   288 IEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSF 352
            ||.||:..:.|||||..|||||....|||.|.....||..|...|::.:|...||..|::||..:
Human   399 IEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIY 463

  Fly   353 ESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHL--ANATGVSPDSGIEFDRWTPSDTGLKXEQS 415
            :..|                      |....:|:  ....||||:.....:..||........:.
Human   464 QGIL----------------------TASRQSHVWEQKVGGVSPEEHPAPEVSTPFPPLPPEPEG 506

  Fly   416 GGKSFV--LPPSQEVPFAAAATSPLPMCLAVNPDNMSPASTTSSSTSTTTTAEAVSVVEMVQHRD 478
            ||:..|  :..||..|.......|......|    |...|....|....:|:|...:.|:....:
Human   507 GGEEKVVGMEESQAAPKEEPGPRPRINLRGV----MRSISLLEPSLELESTSETSDMPEVFSSHE 567

  Fly   479 QEMAE 483
            ....|
Human   568 SSHEE 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723
		DSPc	215..353	CDD:238073	43/129 (33%)
		CDC14	<242..359	CDD:225297	39/116 (34%)
SSH3	NP_060327.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		SSH-N	3..259	CDD:212166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..96
		DEK_C	272..320	CDD:285919
		DSPc	329..464	CDD:238073	43/129 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..534		13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..603		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..638
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940