DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and dusp2

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001003451.1	Gene:	dusp2 / 445057	ZFINID:	ZDB-GENE-040801-188	Length:	333	Species:	Danio rerio

Alignment Length:	332	Identity:	101/332 - (30%)
Similarity:	156/332 - (46%)	Gaps:	47/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQRIQSG-YKLCWFILY 90
            |:||||....:|.:||..:.|:...|::.||.....:.|...:....|..::::| :.....:..
Zfish    31 IVLDCRPFLGFSRAHILESRNVNWNSMLRRRSKSSVVSLEWLVADKSLLAQLRNGDFSPVVVLDE 95

  Fly    91 NGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQAFPEWCEDDNQTH 155
            |...|.....|     |||   ..:||.|...::.....:..||.||:.|...:||.|
Zfish    96 NSRSVRDLKSE-----SLA---SLLISALQSEVQSASTHICFLQGGFDGFFALYPELC------- 145

  Fly   156 SKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNE-APVEII 219
                                    .|.....||:.:..|:.|...   .......|:: .||||:
Zfish   146 ------------------------FTAPAVLCSNHSTLSEPEPVM---SGRKTPLYDQGGPVEIL 183

  Fly   220 PGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDA 284
            | .||||:|.||...|.|::..|..||||:...||.|:|  :::|..:.:.|..:.|:.:.||:|
Zfish   184 P-FLFLGSAHHSSRRETLERNGITAVLNVSSSCPNLFEE--ELQYKTLKVEDSLAADIRVLFPEA 245

  Fly   285 IQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQL 349
            |.||:..:.....|||||.||:|||.|:.||||:|.:.:.|::||..|:.|:..:|||..||.||
Zfish   246 IHFIDSIKEGGGRVLVHCQAGISRSATICLAYLIHAQRVRLDEAFDFVKRRRQVISPNLAFMGQL 310

  Fly   350 LSFESQL 356
            |.||:.:
Zfish   311 LQFETDV 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	31/121 (26%)
		DSPc	215..353	CDD:238073	61/137 (45%)
		CDC14	<242..359	CDD:225297	49/115 (43%)
dusp2	NP_001003451.1	DSP_MapKP	8..145	CDD:238723	31/121 (26%)
dusp2	NP_001003451.1	DSPc	178..314	CDD:238073	61/138 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910