Protein Alignment Mkp3 and dusp8a

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_957174.1
• Gene: dusp8a / 393854
• ZFINID: ZDB-GENE-040426-1842
• Length: 629
• Species: Danio rerio
• Alignment Length: 478
• Identity: 129/478 - (26%)
• Similarity: 200/478 - (41%)
• Gaps: 113/478 - (23%)

  Fly    26 LILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQRIQSGYKLCWFILY 90
            |:::|.|...||:.||:.||:|:|...:|.|||...|:.:...:: |..|.::..|.:
Zfish    27 LLVIDSRTFSEYNASHVHGAINVCCSKLVKRRLQQDKVSVTELLQ-PNGKVKVDLGRR------- 83

  Fly    91 NGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQAFPEWCEDDNQTH 155
              :.|...:|.....|.|  :.||.:.||..:|.....||..|..||..|...||..||
Zfish    84 --QEVVVYDQSTKDTGQL--SKDSFVHILLSKLDSTFHRVSLLTGGFAAFSSCFPGLCE------ 138

  Fly   156 SKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNEAPVEIIP 220
                  .:.|.|        |.:|.:|   .|...|                    |..|..|:|
Zfish   139 ------GKPVAT--------LPMSLSQ---PCLPVA--------------------NVGPTRILP 166

  Fly   221 GLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAI 285
            . |:||:.....:.:.:.:..|.||||.:...| |.:...:..:::||:.|:|.:.|........
Zfish   167 H-LYLGSQKDVLNKDLMAQNGITYVLNASNTCP-KPEFISESHFMRIPVNDNYCEKLLPWLDKTN 229

  Fly   286 QFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLL 350
            :||::|:.::..|:||||||:|||.|:.:||:|.|.|||.:||:..|:||:|.:||||:|:.|||
Zfish   230 EFIDKAKVSNCRVIVHCLAGISRSATIAIAYIMKTMGLSSDDAYRFVKDRRPSISPNFNFLGQLL 294

  Fly   351 SFESQLRLRPG-----------SRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWT 404
            .||..|||...           ..||           :..|..::........:...|.|.|...
Zfish   295 EFEKGLRLLKALSAGQEKLEQLKEFS-----------EPRGESSSDPEKGRLEAEKDGTELDGKL 348

  Fly   405 PSDTGLKXEQSG--------------GKSF------VLPPSQEVPFAAAATSPLP-MCLAVNPD- 447
            ||.|.|: ..:|              .:||      |..|:.....|.|.|..:| :|...:|:
Zfish   349 PSPTSLQQGFNGLNLSAERILDTNRLKRSFSLDIKSVYEPNHCPRLAPAHTEDVPKLCKLDSPEA 413

  Fly   448 ------------NMSPASTTSSS 458
                        ::||....|.|
Zfish   414 REVNGICQHSPVSISPGLAESPS 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	36/121 (30%)
		DSP_MKP_classII	215..352	CDD:350414	53/136 (39%)
dusp8a	NP_957174.1	DSP_MapKP	11..137	CDD:238723	36/121 (30%)
		DSP_DUSP8	150..300	CDD:350493	59/174 (34%)