Protein Alignment Mkp3 and Dusp8

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001101980.1
• Gene: Dusp8 / 361679
• RGDID: 1306425
• Length: 636
• Species: Rattus norvegicus
• Alignment Length: 453
• Identity: 128/453 - (28%)
• Similarity: 194/453 - (42%)
• Gaps: 126/453 - (27%)

  Fly    21 LDSKDL-----------ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPEL 74
            :|:|.|           :::|.|...||:..|:..:||:|...:|.|||..||:.:|..|: |..
  Rat    11 MDAKKLASLLRGGPGGPLVIDSRSFVEYNSCHVLSSVNICCSKLVKRRLQQGKVTIAELIQ-PAA 74

  Fly    75 KQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGC--RVVALQDGF 137
            :.::.:         ...:.|...:|....|..||.  ||.:|||..:|  |||  .|..|..||
  Rat    75 RSQVDA---------TEPQDVVVYDQSTRDASVLAA--DSFLSILLSKL--DGCFDSVAILTGGF 126

  Fly   138 NNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHH 202
            ..|...||..||....|                  |.|:.:              |..|
  Rat   127 ATFSSCFPGLCEGKPAT------------------LPSMSL--------------SQPC------ 153

  Fly   203 HHHHSHHNYNEAPV------EIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNK--FKES 259
                       .||      .|:|. |:||:.....:.:.:.:..|.||||.:...|..  ..||
  Rat   154 -----------LPVPSVGLTRILPH-LYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICES 206

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
               ::::|||.|:|.:.|......:|:||::|:.:|..|:||||||:|||.|:.:||:|.|.|:|
  Rat   207 ---RFMRIPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMS 268

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANA 389
            .:||:..|:||:|.:||||:|:.|||.:|..|:|              ...:|:.|   .||...
  Rat   269 SDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKL--------------LAALQSDG---PHLGTP 316

  Fly   390 TG-VSPDSGIEFDRWTPSD-----TGLK--------XEQSGGKSFVLPPSQEVPFAAAATSPL 438
            .. :.|.:||...|..||.     ||.:        ...:||.:.       :|..|.|||.|
  Rat   317 EPLMGPAAGIPLPRLPPSTSESAATGSEAATAAKEGSPSAGGDAL-------IPSTAPATSAL 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	41/139 (29%)
		DSP_MKP_classII	215..352	CDD:350414	57/144 (40%)
Dusp8	NP_001101980.1	DSP_MapKP	10..137	CDD:238723	41/139 (29%)
		DSP_DUSP8	150..300	CDD:350493	60/170 (35%)