DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and dusp6

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_919361.1	Gene:	dusp6 / 353314	ZFINID:	ZDB-GENE-030613-1	Length:	382	Species:	Danio rerio

Alignment Length:	354	Identity:	148/354 - (41%)
Similarity:	213/354 - (60%)	Gaps:	31/354 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EWLQSQLRSLDSKD-LILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELK 75
            |||:.||.:  .:| |:::|||....|..||:..|:|:.|||::||||..|.:.:.|.:.:.|.:
Zfish    21 EWLKEQLET--RRDCLLVMDCRAQELYESSHVETAINVAIPSLMLRRLKKGNLPIKSLLSNGEDR 83

  Fly    76 QRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNF 140
            :|.....|....:||: |.....|:.|.|.        |::.:|.||:|.:|.:...|:.||:.|
Zfish    84 ERFARRCKTDTIVLYD-EYSREWNENIDGG--------SVLGLLLRRMKDEGYKAFYLEGGFSKF 139

  Fly   141 RQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACS-----SSAESSDCESSS 200
            :..||..||.     :.:..||.:..|.|::||..||||:..||....     |||..||....|
Zfish   140 QTDFPAMCET-----NLDGSSSSSSPTSQVLGLGGLRISSDSSDIESDIDRDPSSATDSDGSPLS 199

  Fly   201 HHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYL 265
            :..        ...||||:|. |:||.|..|.:.:.|:::.|||:|||||:|||.|:.:|:.||.
Zfish   200 NPQ--------PSFPVEILPH-LYLGCAKDSTNLDILEEFGIKYILNVTPNLPNMFENAGEFKYK 255

  Fly   266 QIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFA 330
            ||||:||:||:|:..||:||.||:|||.....||||||||:|||||||:||||....||:|||:.
Zfish   256 QIPISDHWSQNLSQFFPEAISFIDEARGLKCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYD 320

  Fly   331 MVRDRKPDVSPNFHFMQQLLSFESQLRLR 359
            :|:.:|.::||||:||.|||.||..|.|:
Zfish   321 IVKMKKSNISPNFNFMGQLLDFERTLGLK 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	45/136 (33%)
		DSPc	215..353	CDD:238073	79/137 (58%)
		CDC14	<242..359	CDD:225297	71/116 (61%)
dusp6	NP_919361.1	DSP_MapKP	17..147	CDD:238723	45/136 (33%)
		DSPc	206..343	CDD:238073	79/137 (58%)
		CDC14	<232..355	CDD:225297	72/118 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3875
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3168
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm25630
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.970