DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and dusp7

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_956068.3	Gene:	dusp7 / 327246	ZFINID:	ZDB-GENE-030131-5457	Length:	374	Species:	Danio rerio

Alignment Length:	372	Identity:	154/372 - (41%)
Similarity:	211/372 - (56%)	Gaps:	29/372 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPEL 74
            |.||||..|:: ....|:|||||....:..|||..|:||.||.::||||..|.:.:.|.|.:.|.
Zfish    15 SAEWLQEDLQA-GGGSLLLLDCRPHELFESSHIESAINLAIPGLMLRRLKKGNLPIRSIIPNNED 78

  Fly    75 KQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNN 139
            |::.....|....:||:         |...|...:.:..|::.:|.::|:.|||:...|:.|||.
Zfish    79 KEKFVKRCKTDTVLLYD---------EATAAWPESGSAGSVLGLLMQKLRDDGCKAFYLEGGFNK 134

  Fly   140 FRQAFPEWCED--DNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHH 202
            |:..:||.||.  |....|....||       ::||..||||     |.||......:..|::..
Zfish   135 FQTEYPEHCETNLDCSCPSSSPPSS-------VLGLGGLRIS-----SDCSDGESDREPGSATES 187

  Fly   203 HHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQI 267
            ......:|....||:|:| .|:||.|..|.:.:.|.||||||:|||||:|||.|:..|:.||.||
Zfish   188 EGSPLPNNQPAFPVQILP-YLYLGCAKDSTNLDVLGKYNIKYILNVTPNLPNMFEHDGEFKYKQI 251

  Fly   268 PITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMV 332
            ||:||:||:|:..||:||.||:||||....:|||||||:|||||||:||||....||||||:..|
Zfish   252 PISDHWSQNLSQFFPEAISFIDEARSQKCGILVHCLAGISRSVTVTVAYLMQKLNLSLNDAYDFV 316

  Fly   333 RDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTT 379
            :.:|.::||||:||.|||.||..|    |....|...:|......||
Zfish   317 KRKKSNISPNFNFMGQLLDFERTL----GLNSPCDNRSPSDQLFFTT 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	47/137 (34%)
		DSPc	215..353	CDD:238073	82/137 (60%)
		CDC14	<242..359	CDD:225297	72/116 (62%)
dusp7	NP_956068.3	DSP_MapKP	13..143	CDD:238723	47/137 (34%)
		DSPc	200..337	CDD:238073	82/137 (60%)
		CDC14	<226..349	CDD:225297	74/126 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1468
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3168
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm25630
orthoMCL	1	0.900	-	-		OOG6_107960
Panther	1	1.100	-	-	LDO	PTHR10159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980