DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and Dusp2

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001012089.1	Gene:	Dusp2 / 311406	RGDID:	1305804	Length:	318	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	99/357 - (27%)
Similarity:	157/357 - (43%)	Gaps:	90/357 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSKDLILLDCRGSHEYSESHIRGAVNLCIP-SIVLRRLAVG--KIDLASTIKSPELKQRIQSGYK 83
            :::..:|||||....:..||:|.|  ..:| :.:|||.|.|  ...||..:....|:.|:
  Rat    27 EAERTLLLDCRPFLAFCRSHVRAA--RPVPWNALLRRRARGTPAAALACLLPDRALRARL----- 84

  Fly    84 LCWFILYNGEGVPGQNQEIAGAGSL--AVAMDS----------------IISILHRRLKQDGCRV 130
                                |.|.|  ||.:|.                :::.|...::.....|
  Rat    85 --------------------GRGELARAVVLDESSASVAELPPDGPAHLLLAALQHEMRAGPMAV 129

  Fly   131 VALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSD 195
            ..|:.||.:|:...|:.|.:                            :..|:.....:...|||
  Rat   130 CFLRGGFESFQAYCPDLCSE----------------------------APAQALPPAGAENNSSD 166

  Fly   196 CESSSHHHHHHSHHNYNE-APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES 259
            .....          |:: .||||:| .|:||:..||.|.:.|:...|..||||:...||.|:
  Rat   167 PRVPI----------YDQGGPVEILP-YLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFE-- 218

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
            |..:|..||:.|:...:::..|.:||.||:..:::...|||||.||:|||.|:.||||:.:..:.
  Rat   219 GLFRYKSIPVEDNQMVEISAWFQEAIGFIDSVKNSGGRVLVHCQAGISRSATICLAYLIQSHRVR 283

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL 356
            |::||..|:.|:..:||||.||.|||..|:|:
  Rat   284 LDEAFDFVKQRRGVISPNFSFMGQLLQLETQV 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	32/146 (22%)
		DSPc	215..353	CDD:238073	59/137 (43%)
		CDC14	<242..359	CDD:225297	49/115 (43%)
Dusp2	NP_001012089.1	DSP_MapKP	12..147	CDD:238723	32/146 (22%)
Dusp2	NP_001012089.1	DSPc	176..312	CDD:238073	59/138 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910