DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mkp3 and Dusp7

DIOPT Version :9

Sequence 1:NP_001262031.1 Gene:Mkp3 / 40081 FlyBaseID:FBgn0036844 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_001094017.1 Gene:Dusp7 / 300980 RGDID:735026 Length:419 Species:Rattus norvegicus


Alignment Length:356 Identity:152/356 - (42%)
Similarity:204/356 - (57%) Gaps:31/356 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPEL 74
            |.||||.:|.:.....|:|||||....:..|||..|:||.||.::||||..|.:.:.|.|.:...
  Rat    56 SAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHAD 120

  Fly    75 KQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNN 139
            |:|..:..|....:||:......|.:..|.|        |::.:|.::|:.|||:...||.|||.
  Rat   121 KERFATRCKAATVLLYDEATAEWQPEPGAPA--------SVLGLLLQKLRDDGCQAYYLQGGFNK 177

  Fly   140 FRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTT----QSDSACSSSAESSD---CE 197
            |:..:.|.||    |:.....|........::||..||||:.    :||....|||..||   ..
  Rat   178 FQTEYSEHCE----TNVDSSSSPSGSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVP 238

  Fly   198 SSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDI 262
            ||.           ...||:|:| .|:||.|..|.:.:.|.||.|||:|||||:|||.|:..|:.
  Rat   239 SSQ-----------PAFPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEF 291

  Fly   263 KYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLND 327
            .|.||||:||:||:|:..||:||.||:||||....||||||||:|||||||:||||....|||||
  Rat   292 TYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLND 356

  Fly   328 AFAMVRDRKPDVSPNFHFMQQLLSFESQLRL 358
            |:..|:.:|.::||||:||.|||.||..|.|
  Rat   357 AYDFVKRKKSNISPNFNFMGQLLDFERTLGL 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mkp3NP_001262031.1 DSP_MapKP 8..148 CDD:238723 48/137 (35%)
DSPc 215..353 CDD:238073 81/137 (59%)
CDC14 <242..359 CDD:225297 73/117 (62%)
Dusp7NP_001094017.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
DSP_MapKP 55..186 CDD:238723 48/137 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..240 7/23 (30%)
DSP_DUSP7 240..388 CDD:350491 86/160 (54%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q16829 331..337 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 161 1.000 Domainoid score I3914
eggNOG 1 0.900 - - E2759_KOG1717
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1468
Inparanoid 1 1.050 253 1.000 Inparanoid score I3117
OMA 1 1.010 - - QHG52370
OrthoDB 1 1.010 - - D389486at33208
OrthoFinder 1 1.000 - - FOG0002164
OrthoInspector 1 1.000 - - otm46193
orthoMCL 1 0.900 - - OOG6_107960
Panther 1 1.100 - - LDO PTHR10159
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X468
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.840

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