DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and Dusp5

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001078859.1	Gene:	Dusp5 / 240672	MGIID:	2685183	Length:	384	Species:	Mus musculus

Alignment Length:	463	Identity:	127/463 - (27%)
Similarity:	197/463 - (42%)	Gaps:	111/463 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QLRSLDSKD----LILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR 77
            |||.:..|:    .::||||....::.|.:||::|:.:.|:||||...|.:.....:.....:.|
Mouse    10 QLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARAR 74

  Fly    78 -IQSGYKLCWFILYNGEGV-------PGQN--QEIAGAGSLAVAMDSIISILHRRLKQDGCRVVA 132
             :|.|          |.||       .|..  |::....:..|.:.|:::.|     ..|.||..
Mouse    75 LLQEG----------GGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACL-----PAGPRVYF 124

  Fly   133 LQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCE 197
            |:.|:..|...:||.|.|...|..::||..|::.                  |.|.....|....
Mouse   125 LKGGYETFYSQYPECCVDVKPTSQEKIEGERSLL------------------SQCGKPVLSVAYR 171

  Fly   198 SSSHHHHHHSHHNYNE-APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKE--S 259
            .:           |:: .||||:| .|:||:|.|:...|.|...:|..:|||:    .:..|  :
Mouse   172 PA-----------YDQGGPVEILP-FLYLGSAYHASKCEFLANLHITALLNVS----RRTSEACT 220

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
            ..:.|..||:.|.::.|::.||.:||.||:..|.....|||||.||||||.|:.:||||.|:...
Mouse   221 THLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFR 285

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL-----RLRPGSRFSCSCIAPDCNCMQTTGFMAT 384
            |.:||..|:.|:..|||||.||.|||.:||::     .|:|          |.|   |.....:|
Mouse   286 LKEAFDYVKQRRSVVSPNFGFMGQLLQYESEILPSTPTLQP----------PSC---QGEAASST 337

  Fly   385 HLANATGVSPDSGIEFDRWTPSDTGLKXEQSGGKSFVLPPSQEVPFAAAATSPLPMCLAVNPDNM 449
            .:.:...:|||.                           ......|..:..:|:|....|...:.
Mouse   338 FIGHLQTLSPDM---------------------------QGTYCTFRTSVLAPVPTHSTVPELHR 375

  Fly   450 SPASTTSS 457
            ||.:|.:|
Mouse   376 SPVATATS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	37/144 (26%)
		DSPc	215..353	CDD:238073	61/139 (44%)
		CDC14	<242..359	CDD:225297	51/123 (41%)
Dusp5	NP_001078859.1	DSP_MapKP	5..140	CDD:238723	37/144 (26%)
		DSPc	178..314	CDD:238073	61/140 (44%)
		CDC14	<227..318	CDD:225297	45/90 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910