DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and DUSP9

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_011529425.1	Gene:	DUSP9 / 1852	HGNCID:	3076	Length:	415	Species:	Homo sapiens

Alignment Length:	348	Identity:	137/348 - (39%)
Similarity:	204/348 - (58%)	Gaps:	13/348 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR 77
            ||:.:| |.....|:|||||....|..:.|.||:::.:|:::||||..|.:.:.:.:..|.|:..
Human    41 WLRREL-SPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLSVRALLPGPPLQPP 104

  Fly    78 IQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQ 142
            ..:.     .:||:..|...:..| |.|.:.....:|::..|.::|:::|.....||.||:.|:.
Human   105 PPAP-----VLLYDQGGGRRRRGE-AEAEAEEWEAESVLGTLLQKLREEGYLAYYLQGGFSRFQA 163

  Fly   143 AFPEWCEDD--NQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHHHHH 205
            ..|..||..  .:..|........|   .::||.||.:.:..||:...:..:|..|...|.....
Human   164 ECPHLCETSLAGRAGSSMAPVPGPV---PVVGLGSLCLGSDCSDAESEADRDSMSCGLDSEGATP 225

  Fly   206 HSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPIT 270
            .........||:|:|. |:||:|..|.:.|:|.|..|:|:|||||:|||.|:::||..|.||||:
Human   226 PPVGLRASFPVQILPN-LYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPIS 289

  Fly   271 DHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDR 335
            ||:||:|:..||:||:||:||.|.:..||||||||||||||||:||||....||||||:.:|:.:
Human   290 DHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRK 354

  Fly   336 KPDVSPNFHFMQQLLSFESQLRL 358
            |.::||||:||.|||.||..|||
Human   355 KSNISPNFNFMGQLLDFERSLRL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	38/134 (28%)
		DSPc	215..353	CDD:238073	81/137 (59%)
		CDC14	<242..359	CDD:225297	74/117 (63%)
DUSP9	XP_011529425.1	DSP_MapKP	38..169	CDD:238723	38/134 (28%)
		CDC14	224..373	CDD:225297	82/149 (55%)
		DSPc	235..372	CDD:238073	81/137 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I4012
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3206
Isobase	1	0.950	-	0	Normalized mean entropy	S2795
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm42048
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890