Protein Alignment Mkp3 and DUSP8

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_004411.2
• Gene: DUSP8 / 1850
• HGNCID: 3074
• Length: 625
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 124/467 - (26%)
• Similarity: 191/467 - (40%)
• Gaps: 149/467 - (31%)

  Fly    21 LDSKDL-----------ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPEL 74
            :|:|.|           :::|.|...||:..|:..:||:|...:|.|||..||:.:|..|: |..
Human    11 MDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQQGKVTIAELIQ-PAA 74

  Fly    75 KQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGC--RVVALQDGF 137
            :.::::         ...:.|...:|....|..||.  ||.:|||..:|  |||  .|..|..||
Human    75 RSQVEA---------TEPQDVVVYDQSTRDASVLAA--DSFLSILLSKL--DGCFDSVAILTGGF 126

  Fly   138 NNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCESSSHH 202
            ..|...||..||.                                ..:|....:.|..|
Human   127 ATFSSCFPGLCEG--------------------------------KPAALLPMSLSQPC------ 153

  Fly   203 HHHHSHHNYNEAPV------EIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNK--FKES 259
                       .||      .|:|. |:||:.....:.:.:.:..|.||||.:...|..  ..||
Human   154 -----------LPVPSVGLTRILPH-LYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICES 206

  Fly   260 GDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLS 324
               :::::||.|:|.:.|......:|:||::|:.:|..|:||||||:|||.|:.:||:|.|.|:|
Human   207 ---RFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMS 268

  Fly   325 LNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANA 389
            .:||:..|:||:|.:||||:|:.|||.:|..|:|                           ||..
Human   269 SDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKL---------------------------LAAL 306

  Fly   390 TGVSPDSGIEFDRWTPSDTGLKXEQSGGKSFVLPPSQEVPFAAAATSPLPMCLAVNPDNMSPAST 454
            .|         |..|||.|                 .|.|.:.||.:|||        .:.|.::
Human   307 QG---------DPGTPSGT-----------------PEPPPSPAAGAPLP--------RLPPPTS 337

  Fly   455 TSSSTSTTTTAE 466
            .|::|......|
Human   338 ESAATGNAAARE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	41/139 (29%)
		DSP_MKP_classII	215..352	CDD:350414	56/144 (39%)
DUSP8	NP_004411.2	DSP_MapKP	10..137	CDD:238723	41/139 (29%)
		DSP_DUSP8	150..300	CDD:350493	59/170 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..586		17/78 (22%)