DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and DUSP6

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001937.2	Gene:	DUSP6 / 1848	HGNCID:	3072	Length:	381	Species:	Homo sapiens

Alignment Length:	351	Identity:	145/351 - (41%)
Similarity:	208/351 - (59%)	Gaps:	28/351 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR 77
            ||..|| .|.::.|:|:|||....|..|||..|:|:.||.|:||||..|.:.:.:.....|.:.|
Human    22 WLNEQL-ELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDR 85

  Fly    78 IQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFNNFRQ 142
            ..........:||: |.....|:...|        :|::.:|.::||.:|||...|:.||:.|:.
Human    86 FTRRCGTDTVVLYD-ESSSDWNENTGG--------ESVLGLLLKKLKDEGCRAFYLEGGFSKFQA 141

  Fly   143 AFPEWCEDDNQTHSKEIESSRNVQTDQL--MGLRSLRISTTQSDSACSSSAESS---DCESSSHH 202
            .|...||.:       ::.|.:..:..|  :||..||||   |||  ||..||.   |..|::..
Human   142 EFSLHCETN-------LDGSCSSSSPPLPVLGLGGLRIS---SDS--SSDIESDLDRDPNSATDS 194

  Fly   203 HHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQI 267
            ......::....||||:| .|:||.|..|.:.:.|:::.|||:|||||:|||.|:.:|:.||.||
Human   195 DGSPLSNSQPSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQI 258

  Fly   268 PITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMV 332
            ||:||:||:|:..||:||.||:|||..:..||||||||:|||||||:||||....||:|||:.:|
Human   259 PISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIV 323

  Fly   333 RDRKPDVSPNFHFMQQLLSFESQLRL 358
            :.:|.::||||:||.|||.||..|.|
Human   324 KMKKSNISPNFNFMGQLLDFERTLGL 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	43/134 (32%)
		DSPc	215..353	CDD:238073	79/137 (58%)
		CDC14	<242..359	CDD:225297	72/117 (62%)
DUSP6	NP_001937.2	DSP_MapKP	17..147	CDD:238723	43/134 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..203		7/28 (25%)
		DSPc	207..344	CDD:238073	79/137 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I4012
eggNOG	1	0.900	-	-		E2759_KOG1717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3206
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm42048
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2281
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.970