Protein Alignment Mkp3 and DUSP5

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_004410.3
• Gene: DUSP5 / 1847
• HGNCID: 3071
• Length: 384
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 124/464 - (26%)
• Similarity: 197/464 - (42%)
• Gaps: 111/464 - (23%)

  Fly    14 LQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR- 77
            |:..||...:...::||||....::.|::||::|:.:.|:||||...|.:.....:.....:.|
Human    11 LRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARARL 75

  Fly    78 IQSGYKLCWFILYNGEGV-------PGQN--QEIAGAGSLAVAMDSIISILHRRLKQDGCRVVAL 133
            :|.|          |.||       .|..  |::....:..|.:.|:::.|     ..|.||..|
Human    76 LQEG----------GGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACL-----PAGPRVYFL 125

  Fly   134 QDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCES 198
            :.|:..|...:||.|.|......::|||.|                           |..|.|..
Human   126 KGGYETFYSEYPECCVDVKPISQEKIESER---------------------------ALISQCGK 163

  Fly   199 SSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKE--SGD 261
            ...:..:...::.. .||||:| .|:||:|.|:...|.|...:|..:|||:    .:..|  :..
Human   164 PVVNVSYRPAYDQG-GPVEILP-FLYLGSAYHASKCEFLANLHITALLNVS----RRTSEACATH 222

  Fly   262 IKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLN 326
            :.|..||:.|.::.|::.||.:||.||:..|.....|||||.||:|||.|:.:||||.|:...|.
Human   223 LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLK 287

  Fly   327 DAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATG 391
            :||..::.|:..|||||.||.|||.:||::                             |.:...
Human   288 EAFDYIKQRRSMVSPNFGFMGQLLQYESEI-----------------------------LPSTPN 323

  Fly   392 VSPDSGIEFDRWTPSDTGLKXEQSGGKSFV-----LPPSQE---VPFAAAATSPLPMCLAVNPDN 448
            ..|          ||..|    ::.|.|.:     |.|..:   ..|.|:..:|:|....|:..:
Human   324 PQP----------PSCQG----EAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELS 374

  Fly   449 MSPASTTSS 457
            .||.:|.:|
Human   375 RSPVATATS 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	36/143 (25%)
		DSP_MKP_classII	215..352	CDD:350414	59/138 (43%)
DUSP5	NP_004410.3	DSP_MapKP	5..140	CDD:238723	36/143 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	53..74		3/20 (15%)
		DSP_DUSP5	179..316	CDD:350487	60/141 (43%)