Protein Alignment Mkp3 and DUSP4

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_001385.1
• Gene: DUSP4 / 1846
• HGNCID: 3070
• Length: 394
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 130/442 - (29%)
• Similarity: 200/442 - (45%)
• Gaps: 105/442 - (23%)

  Fly    27 ILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKS-PELKQRIQSGYKLCWFILY 90
            :|||||....:|..:|.|:||:...:|| ||.|.|.:.|...:.: .|::.|::||       ||
Human    46 LLLDCRPFLAHSAGYILGSVNVRCNTIV-RRRAKGSVSLEQILPAEEEVRARLRSG-------LY 102

  Fly    91 NGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCR--VVALQDGFNNFRQAFPEWCEDDNQ 153
            :...|..:....|.    ::..||.:|::.:.|:::..|  :..|:.|:..|...:||:|.
Human   103 SAVIVYDERSPRAE----SLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCS---- 159

  Fly   154 THSKEIESSRNVQTDQLMGL-RSLRISTTQS-DSACSSSAESSDCESSSHHHHHHSHHNYNEAPV 216
                        :|..|..: ..:..|.|:. |..|||      |.:..|.         ...||
Human   160 ------------KTKALAAIPPPVPPSATEPLDLGCSS------CGTPLHD---------QGGPV 197

  Fly   217 EIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHF 281
            ||:| .|:||:|.|:...:.|....|..:|||:.|.||.|:  |..:|..||:.|::..|::..|
Human   198 EILP-FLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFE--GHYQYKCIPVEDNHKADISSWF 259

  Fly   282 PDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFM 346
            .:||::|:..:.....|||||.||:|||.|:.|||||..:.:.|.:||..|:.|:..:||||.||
Human   260 MEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFM 324

  Fly   347 QQLLSFESQLRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANATGVSPDSGIEFDRWTPSDTGLK 411
            .|||.||||:                         :||..| |...||...:
Human   325 GQLLQFESQV-------------------------LATSCA-AEAASPSGPL------------- 350

  Fly   412 XEQSGGKSFVLPPSQEV---PFAA---AATSPLPMCLAVNPDNMSPASTTSS 457
              :..||:...|.||.|   |.:.   :|.|.||..       .||.:|:.|
Human   351 --RERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYL-------HSPITTSPS 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	35/123 (28%)
		DSP_MKP_classII	215..352	CDD:350414	59/136 (43%)
DUSP4	NP_001385.1	DSP_MapKP	9..158	CDD:238723	35/123 (28%)
		DSP_DUSP4	196..336	CDD:350488	63/167 (38%)