Protein Alignment Mkp3 and DUSP2

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: XP_054196891.1
• Gene: DUSP2 / 1844
• HGNCID: 3068
• Length: 390
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 110/379 - (29%)
• Similarity: 166/379 - (43%)
• Gaps: 106/379 - (27%)

  Fly    22 DSKDLILLDCRGSHEYSESHIRGAVNLCIP-SIVLRRLAVG--KIDLASTIKSPELKQRIQSGYK 83
            :::..:|||||....:...|:|.|  ..:| :.:|||.|.|  ...||..:....|:.|:..|
Human    71 EAERTLLLDCRPFLAFCRRHVRAA--RPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRG-- 131

  Fly    84 LCWFILYNGEGVPGQNQEIAGA-----GSLAVA---MDS-----IISILHR-----------RLK 124
                             |:|.|     ||.:||   .||     :.::||.           |.:
Human   132 -----------------ELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRAGPTAVYFLRGE 179

  Fly   125 QDG----------------CRVVALQDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGL 173
            |.|                ..:..|..||:.|:...|:.|.:                 .....|
Human   180 QAGRPWPAPPDSSPAFPADRALPLLAGGFDGFQGCCPDLCSE-----------------APAPAL 227

  Fly   174 RSLRISTTQSDSACSSSAESSDCESSSHHHHHHSHHNYNE-APVEIIPGLLFLGNATHSCDSEAL 237
            ......|::|||....                     |:: .||||:| .||||:.:||.|.:.|
Human   228 PPTGDKTSRSDSRAPV---------------------YDQGGPVEILP-YLFLGSCSHSSDLQGL 270

  Fly   238 KKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHC 302
            :...|..||||:...||.|:  |..:|..||:.|:...:::..|.:||.||:..:::...|||||
Human   271 QACGITAVLNVSASCPNHFE--GLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHC 333

  Fly   303 LAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL 356
            .||:|||.|:.|||||.:|.:.|::||..|:.|:..:||||.||.|||.||:|:
Human   334 QAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQV 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	38/168 (23%)
		DSP_MKP_classII	215..352	CDD:350414	62/136 (46%)
DUSP2	XP_054196891.1	DSP_MapKP	56..219	CDD:238723	38/168 (23%)
		DSP_DUSP2	246..389	CDD:350489	65/145 (45%)