Protein Alignment Mkp3 and Dusp5

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_598262.2
• Gene: Dusp5 / 171109
• RGDID: 620854
• Length: 384
• Species: Rattus norvegicus
• Alignment Length: 458
• Identity: 125/458 - (27%)
• Similarity: 195/458 - (42%)
• Gaps: 99/458 - (21%)

  Fly    14 LQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIKSPELKQR- 77
            |:..||.......::||||....::.|.:||::|:.:.|:||||...|.:.....:.....:.|
  Rat    11 LRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARARL 75

  Fly    78 IQSGYKLCWFILYNGEGV-------PGQN--QEIAGAGSLAVAMDSIISILHRRLKQDGCRVVAL 133
            :|.|          |.||       .|..  |::....:..|.:.|:::.|     ..|.||..|
  Rat    76 LQEG----------GGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACL-----PAGPRVYFL 125

  Fly   134 QDGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESSDCES 198
            :.|:..|...:||.|.|           ::.:..::|.|.|.|.       |.|.....|.....
  Rat   126 KGGYETFYSQYPECCVD-----------AKPISQEKLEGERGLL-------SQCGKPILSVAYRP 172

  Fly   199 SSHHHHHHSHHNYNE-APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKE--SG 260
            :           |:: .||||:| .|:||:|.|:...|.|...:|..:|||:    .:..|  :.
  Rat   173 A-----------YDQGGPVEILP-FLYLGSAYHASKCEFLANLHITALLNVS----RRTSEACTT 221

  Fly   261 DIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSL 325
            .:.|..||:.|.::.|::.||.:||.||:..|.....|||||.||||||.|:.:||||.|:...|
  Rat   222 HLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFRL 286

  Fly   326 NDAFAMVRDRKPDVSPNFHFMQQLLSFESQ-LRLRPGSRFSCSCIAPDCNCMQTTGFMATHLANA 389
            .:||..::.|:..|||||.||.|||.:||: |...|..:      .|.|   |.....:|.:.:.
  Rat   287 KEAFEYIKQRRSVVSPNFGFMGQLLQYESEILPSTPTPQ------PPSC---QGEAASSTFIGHL 342

  Fly   390 TGVSPDSGIEFDRWTPSDTGLKXEQSGGKSFVLPPSQEVPFAAAATSPLPMCLAVNPDNMSPAST 454
            ..:|||.                           ......|..:..:|:|....|...:.||.:|
  Rat   343 QTLSPDM---------------------------QGAYCTFPTSVLAPVPTHATVAELHRSPVAT 380

  Fly   455 TSS 457
            .:|
  Rat   381 ATS 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	36/143 (25%)
		DSP_MKP_classII	215..352	CDD:350414	60/138 (43%)
Dusp5	NP_598262.2	DSP_MapKP	5..140	CDD:238723	36/143 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	53..74		3/20 (15%)
		DSP_DUSP5	179..316	CDD:350487	61/141 (43%)