Protein Alignment Mkp3 and DUSP10

DIOPT Version :10

• Sequence 1: NP_001262031.1
• Gene: Mkp3 / 40081
• FlyBaseID: FBgn0036844
• Length: 497
• Species: Drosophila melanogaster
• Sequence 2: NP_009138.1
• Gene: DUSP10 / 11221
• HGNCID: 3065
• Length: 482
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 117/363 - (32%)
• Similarity: 175/363 - (48%)
• Gaps: 77/363 - (21%)

  Fly     9 CSKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNL-CIPSIVLRRLAVGKI---DLASTI 69
            |||..|.||       ..:::|||...||::|||:|||:: |...|..|||..|||   ||.|..
Human   162 CSKSHLPSQ-------GPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCR 219

  Fly    70 KSPELKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQ 134
            :..:..:||.|..    .|:|:..  ..:...:..:..|.:.::|        ||::|...:.|:
Human   220 EGKDSFKRIFSKE----IIVYDEN--TNEPSRVMPSQPLHIVLES--------LKREGKEPLVLK 270

  Fly   135 DGFNNFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAESS----- 194
            .|.::|:|.....|:     :|.:::..|.|                    ...:||.||
Human   271 GGLSSFKQNHENLCD-----NSLQLQECREV--------------------GGGASAASSLLPQP 310

  Fly   195 -----DCESSSHHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPN 254
                 |.|              |.....|:| .|||||...:.|.:.:::.||.||:|||..||.
Human   311 IPTTPDIE--------------NAELTPILP-FLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL 360

  Fly   255 KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLM- 318
            ...|.|...|.::|.||...|:|..:|.:|.:|||||......:|:||.||||||.|:.:||||
Human   361 YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMK 425

  Fly   319 HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL 356
            ||| :::.||:..|:.::|.:|||.:||.|||.||..|
Human   426 HTR-MTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	42/142 (30%)
		DSP_MKP_classII	215..352	CDD:350414	61/137 (45%)
DUSP10	NP_009138.1	DSP_MapKP	149..284	CDD:238723	42/142 (30%)
		Interaction with MAP kinases	199..215		7/15 (47%)
		DSP_DUSP10	322..473	CDD:350415	64/143 (45%)