DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkp3 and dusp9

DIOPT Version :9

Sequence 1:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_002935558.1	Gene:	dusp9 / 100493388	XenbaseID:	XB-GENE-986835	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	369	Identity:	144/369 - (39%)
Similarity:	207/369 - (56%)	Gaps:	33/369 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKEWLQSQLRSLDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLASTIK-SPE 73
            |..||:.:|.|: |::|.:||||....|..||:..|:::.:|.::||||..|.:...|.:. ||.
Frog     7 STAWLRDELVSV-SQNLRILDCRARELYDSSHVEKALHVALPGLMLRRLRKGNLSAHSLLPGSPP 70

  Fly    74 LKQRIQSGYKLCWFILYNGEGVPGQNQEIAGAGSLAVAMDSIISILHRRLKQDGCRVVALQDGFN 138
            ..:.:...|..|...|.:.|...|..||           ..::.:|| :|:::||:...||.||:
Frog    71 TVRGVALLYDECTSSLESLEANHGDEQE-----------PILVMLLH-KLRKEGCQAYYLQGGFS 123

  Fly   139 NFRQAFPEWCEDDNQTHSKEIESSRNVQTDQLMGLRSLRISTTQSDSACSSSAE---SSDCESSS 200
            .|:..||..||  .........|:..:.|..::||..|.|::..||.......|   ..|.|..|
Frog   124 KFQAEFPHHCE--TNLDCTNCASNSPLPTTPVLGLGGLSITSDCSDFESDLDREPLSGVDSEGMS 186

  Fly   201 HHHHHHSHHNYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYL 265
            ..:...|.      ||:|:|. |:||:|..|.:.:.|.|..|:|:|||||:|||.|::.|:..|.
Frog   187 PRNQAPSF------PVQILPH-LYLGSARDSGNIDTLAKLGIRYILNVTPNLPNIFEKDGEFHYK 244

  Fly   266 QIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFA 330
            ||||:||:||:|:..||:||:||:||.|.:..||||||||:|||||||:||||....||||||:.
Frog   245 QIPISDHWSQNLSQFFPEAIEFIDEAASHNCGVLVHCLAGISRSVTVTVAYLMQKLNLSLNDAYD 309

  Fly   331 MVRDRKPDVSPNFHFMQQLLSFESQLRLR-------PGSRFSCS 367
            .|:.:|.::||||:||.|||.||..|.|.       ||..|..|
Frog   310 FVKRKKTNISPNFNFMGQLLDFEKSLGLSSPEDNRPPGHSFFTS 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723	43/138 (31%)
		DSPc	215..353	CDD:238073	78/137 (57%)
		CDC14	<242..359	CDD:225297	70/116 (60%)
dusp9	XP_002935558.1	DSP_MapKP	6..133	CDD:238723	43/138 (31%)
dusp9	XP_002935558.1	DSP_DUSP9	193..337	CDD:350492	82/150 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3821
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3115
OMA	1	1.010	-	-		QHG52370
OrthoDB	1	1.010	-	-		D389486at33208
OrthoFinder	1	1.000	-	-		FOG0002164
OrthoInspector	1	1.000	-	-		otm49277
Panther	1	1.100	-	-	O	PTHR10159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X468
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080