Protein Alignment Ugt316A1 and UGT8

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 134/529 - (25%)
• Similarity: 232/529 - (43%)
• Gaps: 66/529 - (12%)

  Fly    14 GIVLGANVLTVFPSVWKSH-YLFGRRLLQELVESSGNHSVTLISPHAAQEGVDAEIPKIREL-RI 76
            ||...|.::.|.|.:::|| |:|  :.|...:...|:|:|.|:|     ||.|........| |.
Human    16 GIAKAAKIIIVPPIMFESHMYIF--KTLASALHERGHHTVFLLS-----EGRDIAPSNHYSLQRY 73

  Fly    77 EGLRENWLDMGMSFEAEEMRAQSVMERFTRLIYAG--------------TTNVDILLSDPQVRKL 127
            .|:        .:....:...||.|    |.|::|              |.|.|:::.:..:.:.
Human    74 PGI--------FNSTTSDAFLQSKM----RNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQG 126

  Fly   128 LTSGEKFDLLIVDL-----FLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNF 187
            |.. ||||||:||.     |:...|||:.:       ||..||.  |.....|.|...:..|...
Human   127 LKK-EKFDLLLVDPNDMCGFVIAHLLGVKY-------AVFSTGL--WYPAEVGAPAPLAYVPEFN 181

  Fly   188 LPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSLALIN 252
            ...|:|||..||:.|:.:....||..:|..|...:.:...:  .|:.|..:| ||....||.::.
Human   182 SLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKY--NLLPEKSMY-DLVHGSSLWMLC 243

  Fly   253 SHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESA-PSGVIYFSLGADVETAQLPQEK 316
            :...|.:||..|||:|.|||:.....:.  ||:.|..::..| ..|.:..|.||.|:  .|.::.
Human   244 TDVALEFPRPTLPNVVYVGGILTKPASP--LPEDLQRWVNGANEHGFVLVSFGAGVK--YLSEDI 304

  Fly   317 LAIILDVFGHLKEFHFLLKWEKEEFTAEQV--LPENVMIADWWPQQAILHHPQVKMFISSCGQLS 379
            ...:....|.|.:   .:.|   .|:..:.  |..|..:.:|.||..:|.|.::|.|:|..|..|
Human   305 ANKLAGALGRLPQ---KVIW---RFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNS 363

  Fly   380 VWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQ 444
            ::|:|....||:.||:..:......|:|..|:.:.:.:.::....|...:.::..|.||.::..:
Human   364 IFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQK 428

  Fly   445 LKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFGILTIPF 509
            |.|....:...||.:.:..|..|:...||..|::..:.::|.:...:|:..::.:|...:..:..
Human   429 LSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLS 493

  Fly   510 LAICFILRK 518
            ....||.||
Human   494 WVTKFIYRK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	120/465 (26%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	130/522 (25%)