Protein Alignment Ugt316A1 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 129/567 - (22%)
• Similarity: 239/567 - (42%)
• Gaps: 119/567 - (20%)

  Fly     4 LQVFLGTLLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQEGVDAEI 68
            |..:..:..||.||      |:|:.: ||::..:.:|:|||:.  .|.||::: .:|...|:|.
Human    14 LSCYFSSGSCGKVL------VWPTEY-SHWINMKTILEELVQR--GHEVTVLT-SSASTLVNAS- 67

  Fly    69 PKIRELRIE----GLRENWLDMGMSFEAEEMRAQSVMERFTRLIYAGTTNV-------------- 115
             |...:::|    .|.:|:|:            .|:::...|.||..:.|.
Human    68 -KSSAIKLEVYPTSLTKNYLE------------DSLLKILDRWIYGVSKNTFWSYFSQLQELCWE 119

  Fly   116 ----------DILLSDPQVRKLLTSGEKFDLLIVDLF-----LSDALLGLAFYYGIPTVAVSPTG 165
                      |.:|:...:.||..|  |||:::.|..     |...|..:.|.|.: ..:|..|
Human   120 YYDYSNKLCKDAVLNKKLMMKLQES--KFDVILADALNPCGELLAELFNIPFLYSL-RFSVGYT- 180

  Fly   166 ANSWLNNMFGNPQSSSLDPSNFLP-----FTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVY 225
                    |.......|.|.:::|     .:::|...:||.|.:...:....:..:.|......|
Human   181 --------FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFY 237

  Fly   226 TNHFELLVKELPLYRDLTKNLSLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSF 290
            :   |:|.:...|:..:.| ..:.||.::....:||.:|||:..|||||......  |||.:..|
Human   238 S---EVLGRPTTLFETMGK-AEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKP--LPKEMEEF 296

  Fly   291 MESA-PSGVIYFSLGADVET-------------AQLPQEKLAIILDVFGHLKEFHFLLKWEKEEF 341
            ::|: .:|::.||||:.:..             ||:||:.|                  |   .|
Human   297 VQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVL------------------W---RF 340

  Fly   342 TAEQ--VLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAK 404
            ..::  .|..|..:..|.||..:|.||:.|.||:..|...::|:|....|::.||:.|:|.....
Human   341 DGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIA 405

  Fly   405 RLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQLILE 469
            .::..|.:::|...:::...||:.::.:..:..|.|.:.:|......:...|:.:||..|:.::.
Human   406 HMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMR 470

  Fly   470 SGGADFLKSHANTLNFWRAEGVDVL--LIIAVGFFGILTIPFLAICF 514
            ..||..|:..|:.|.:.:...:||:  |:..|.....:...|...||
Human   471 HKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCF 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	109/495 (22%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	127/557 (23%)