Protein Alignment Ugt316A1 and UGT2B10

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 120/552 - (21%)
• Similarity: 238/552 - (43%)
• Gaps: 92/552 - (16%)

  Fly     4 LQVFLGTLLCGIVLGANVLTVFPSVWKSHY---LFGRRLLQELVESSGNHSVTLISPHAA----- 60
            |..:..:..||.||          ||.:.|   :..:.:|:|||:.  .|.||:::..|:
Human    13 LSFYFSSGSCGKVL----------VWAAEYSLWMNMKTILKELVQR--GHEVTVLASSASILFDP 65

  Fly    61 -------------------QEGVDAEIPKIRELRIEGLRENWLDMGMSFEAEEMRA-QSVMERFT 105
                               .|.:..::.|    |:..::::...:..|.|.|.:.| ..::..|.
Human    66 NDSSTLKLEVYPTSLTKTEFENIIMQLVK----RLSEIQKDTFWLPFSQEQEILWAINDIIRNFC 126

  Fly   106 RLIYAGTTNVDILLSDPQVRKLLTSGEKFDLLIVDLFLSDALLGLAFYYGIPTV---AVSPTGAN 167
            :         |::.:...::||..|  :||::..|.:|....| ||..:.||.|   :.||
Human   127 K---------DVVSNKKLMKKLQES--RFDIVFADAYLPCGEL-LAELFNIPFVYSHSFSP---- 175

  Fly   168 SWLNNMFGNPQSSSLDPSNFLP-----FTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTN 227
               ...|.......:.|.:::|     .:::|...:|:.|.|...:....:..|::......|:
Human   176 ---GYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYS- 236

  Fly   228 HFELLVKELPLYRDLTKNLSLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME 292
              |:|.:...|...:.| ..:.|:.:.....:|..:|||:..|||||......  |||.:..|::
Human   237 --EVLGRPTTLSETMRK-ADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKP--LPKEMEEFVQ 296

  Fly   293 SA-PSGVIYFSLGADVETAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADW 356
            |: .:||:.||||:.|  :.:.:|:..:|......:.:   .:.| :.:......|..|..:..|
Human   297 SSGENGVVVFSLGSMV--SNMTEERANVIATALAKIPQ---KVLW-RFDGNKPDALGLNTRLYKW 355

  Fly   357 WPQQAILHHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLA 421
            .||..:|.||:.:.||:..|...::|:|....|::.||:..:|......::..|.:|.|.:::::
Human   356 IPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS 420

  Fly   422 YDSLLHGIRQLTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFW 486
            ...||:.::.:..:.||.|.:.:|......:...|:.:||..|:.::...||..|:..|:.|.::
Human   421 STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWF 485

  Fly   487 RAEGVDVLLIIAVGFFGILTIPFLAICFILRK 518
            :...:||:        |.|......:.||:.|
Human   486 QYHSLDVI--------GFLLACVATVLFIITK 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	100/478 (21%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	118/542 (22%)